Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Metabotropic glutamate receptor 5' and Ligand = 'BDBM308239'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM308239 (US9650377, Example 126) Show SMILES CC(C)(C)[Si](OCc1cn(cn1)C1=NCC(=O)N2CCc3c(cccc3C2=C1)C1CC1)(c1ccccc1)c1ccccc1 |c:29,t:13| Show InChI InChI=1S/C36H38N4O2Si/c1-36(2,3)43(28-11-6-4-7-12-28,29-13-8-5-9-14-29)42-24-27-23-39(25-38-27)34-21-33-32-16-10-15-30(26-17-18-26)31(32)19-20-40(33)35(41)22-37-34/h4-16,21,23,25-26H,17-20,22,24H2,1-3H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description Activity of compounds of the present invention with respect to mGluR1 antagonism was examined by an assay based on measurements of L-glutamate induce...				US Patent US9650377 (2017) BindingDB Entry DOI: 10.7270/Q2G73GT2
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