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Found 1 hit Enz. Inhib. hit(s) with Target = 'Metabotropic glutamate receptor 5' and Ligand = 'BDBM50022816'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Metabotropic glutamate receptor 5


(Rattus norvegicus (Rat))		BDBM50022816
PNG
(CHEMBL3298453)
Show SMILES Fc1ccc(nc1)N1CCc2nc(OCc3cccc(F)c3)ccc2C1=O
Show InChI InChI=1S/C20H15F2N3O2/c21-14-3-1-2-13(10-14)12-27-19-7-5-16-17(24-19)8-9-25(20(16)26)18-6-4-15(22)11-23-18/h1-7,10-11H,8-9,12H2
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Article
PubMed
n/an/an/an/a 214n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulator activity at rat mGlu5 receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced calcium mobiliza...

J Med Chem 57: 5620-37 (2014)


Article DOI: 10.1021/jm500259z
BindingDB Entry DOI: 10.7270/Q2736SHB
More data for this
Ligand-Target Pair