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Found 1 hit Enz. Inhib. hit(s) with Target = 'Metabotropic glutamate receptor 5' and Ligand = 'BDBM50438305'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50438305
PNG
(CHEMBL2408585)
Show SMILES Clc1cccc(Nc2ncc3C(=O)CCCc3n2)c1
Show InChI InChI=1S/C14H12ClN3O/c15-9-3-1-4-10(7-9)17-14-16-8-11-12(18-14)5-2-6-13(11)19/h1,3-4,7-8H,2,5-6H2,(H,16,17,18)
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Article
PubMed
n/an/a 120n/an/an/an/an/an/a



Merz Pharmaceuticals GmbH

Curated by ChEMBL


Assay Description
Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...

Bioorg Med Chem Lett 23: 4493-500 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.049
BindingDB Entry DOI: 10.7270/Q2KD20B8
More data for this
Ligand-Target Pair