Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Mitogen-activated protein kinase 1' and Ligand = 'BDBM180967'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM180967 (US9133187, I-120) Show SMILES CC(C)Nc1ncc2CCN(Cc2n1)C(=O)N[C@@H]1CN(C)C[C@H]1c1ccc(c(F)c1)C(F)(F)F |r| Show InChI InChI=1S/C23H28F4N6O/c1-13(2)29-21-28-9-15-6-7-33(12-19(15)30-21)22(34)31-20-11-32(3)10-16(20)14-4-5-17(18(24)8-14)23(25,26)27/h4-5,8-9,13,16,20H,6-7,10-12H2,1-3H3,(H,31,34)(H,28,29,30)/t16-,20+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.60	n/a	n/a	n/a	n/a	7.3	n/a
ARRAY BIOPHARMA INC.; GENENTECH, INC. US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...				US Patent US9133187 (2015) BindingDB Entry DOI: 10.7270/Q28W3C2N
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