Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Mitogen-activated protein kinase 1' and Ligand = 'BDBM275139'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM275139 (1-[1-(2-methyl-2H-indazol- 5-yl)-1H-pyrazolo[3,4- ...) Show SMILES Cn1cc2cc(ccc2n1)-n1ncc2cc(NC(=O)NC(c3cnco3)c3ccccc3)ncc12 Show InChI InChI=1S/C25H20N8O2/c1-32-14-18-9-19(7-8-20(18)31-32)33-21-12-27-23(10-17(21)11-28-33)29-25(34)30-24(22-13-26-15-35-22)16-5-3-2-4-6-16/h2-15,24H,1H3,(H2,27,29,30,34)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.56	n/a	n/a	n/a	n/a	n/a	n/a
MERCK SHARP & DOHME CORP. US Patent					Assay Description Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each compound was dete...				US Patent US9884048 (2018) BindingDB Entry DOI: 10.7270/Q29G5PT5
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