Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mitogen-activated protein kinase 1 (Homo sapiens (Human)) | BDBM50021740 (CHEMBL3298304) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 43 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma Inc Curated by ChEMBL | Assay Description Inhibition of human recombinant N-terminal 6-His-tagged ERK2 expressed in Escherichia coli using S/T17 as substrate after 30 mins by spectrophotometr... | Bioorg Med Chem Lett 24: 2635-9 (2014) Article DOI: 10.1016/j.bmcl.2014.04.068 BindingDB Entry DOI: 10.7270/Q2FQ9Z54 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 1 (Homo sapiens (Human)) | BDBM50021740 (CHEMBL3298304) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 2.26E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma Inc Curated by ChEMBL | Assay Description Inhibition of ERK2 in human HepG2 cells assessed as P90RSK phosphorylation at Ser380 after 1.5 hrs by fluorescence assay | Bioorg Med Chem Lett 24: 2635-9 (2014) Article DOI: 10.1016/j.bmcl.2014.04.068 BindingDB Entry DOI: 10.7270/Q2FQ9Z54 | |||||||||||
More data for this Ligand-Target Pair |