Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'Mitogen-activated protein kinase 14' and Ligand = 'BDBM236615'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM236615 (US9388136, Table 1, Compound 1:tert-Butyl N-(2-{4-...) Show SMILES C[C@H](NCCc1cc(F)c(c(F)c1)-n1c(N)c(ccc1=O)C(=O)c1ccc(F)cc1F)C(=O)OC(C)(C)C |r,wD:1.0,(6.67,-.38,;6.67,1.15,;5.33,1.93,;4,1.15,;2.67,1.93,;1.33,1.15,;,1.93,;-1.33,1.15,;-2.67,1.93,;-1.33,-.38,;,-1.15,;,-2.69,;1.33,-.38,;-2.67,-1.15,;-4,-.38,;-4,1.15,;-5.33,-1.15,;-5.33,-2.69,;-4,-3.47,;-2.67,-2.69,;-1.33,-3.47,;-6.67,-.38,;-6.67,1.15,;-8,-1.15,;-9.34,-.38,;-10.67,-1.15,;-10.67,-2.69,;-12,-3.47,;-9.34,-3.47,;-8,-2.69,;-6.67,-3.47,;8,1.93,;8,3.47,;9.34,1.15,;10.67,1.93,;12,1.15,;10.67,3.47,;11.07,.44,)| Show InChI InChI=1S/C27H27F4N3O4/c1-14(26(37)38-27(2,3)4)33-10-9-15-11-20(30)23(21(31)12-15)34-22(35)8-7-18(25(34)32)24(36)17-6-5-16(28)13-19(17)29/h5-8,11-14,33H,9-10,32H2,1-4H3/t14-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	7.5	25
Chroma Therapeutics Ltd US Patent					Assay Description The ability of compounds to inhibit p38 MAP a Kinase activity was measured in an assay performed by Upstate (Dundee UK). In a final reaction volume o...				US Patent US9388136 (2016) BindingDB Entry DOI: 10.7270/Q2M61J5H
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM236615 (US9388136, Table 1, Compound 1:tert-Butyl N-(2-{4-...) Show SMILES C[C@H](NCCc1cc(F)c(c(F)c1)-n1c(N)c(ccc1=O)C(=O)c1ccc(F)cc1F)C(=O)OC(C)(C)C |r,wD:1.0,(6.67,-.38,;6.67,1.15,;5.33,1.93,;4,1.15,;2.67,1.93,;1.33,1.15,;,1.93,;-1.33,1.15,;-2.67,1.93,;-1.33,-.38,;,-1.15,;,-2.69,;1.33,-.38,;-2.67,-1.15,;-4,-.38,;-4,1.15,;-5.33,-1.15,;-5.33,-2.69,;-4,-3.47,;-2.67,-2.69,;-1.33,-3.47,;-6.67,-.38,;-6.67,1.15,;-8,-1.15,;-9.34,-.38,;-10.67,-1.15,;-10.67,-2.69,;-12,-3.47,;-9.34,-3.47,;-8,-2.69,;-6.67,-3.47,;8,1.93,;8,3.47,;9.34,1.15,;10.67,1.93,;12,1.15,;10.67,3.47,;11.07,.44,)| Show InChI InChI=1S/C27H27F4N3O4/c1-14(26(37)38-27(2,3)4)33-10-9-15-11-20(30)23(21(31)12-15)34-22(35)8-7-18(25(34)32)24(36)17-6-5-16(28)13-19(17)29/h5-8,11-14,33H,9-10,32H2,1-4H3/t14-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12	n/a	n/a	n/a	n/a	7.5	25
Chroma Therapeutics Ltd US Patent					Assay Description The ability of compounds to inhibit p38 MAP a Kinase activity was measured in an assay performed by Upstate (Dundee UK). In a final reaction volume o...				US Patent US9388136 (2016) BindingDB Entry DOI: 10.7270/Q2M61J5H
					More data for this Ligand-Target Pair