Found 3 hits Enz. Inhib. hit(s) with Target = 'Mitogen-activated protein kinase 14' and Ligand = 'BDBM50175757' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50175757
((2S)-2-(4-(5-(2-chloro-4-fluorophenyl)-1-(2,6-dich...)Show SMILES C[C@H](N1CCC(CC1)c1cc(-c2ccc(F)cc2Cl)c2ccc(=O)n(-c3c(Cl)cccc3Cl)c2c1)C(O)=O |wU:1.0,(22.43,-33.2,;22.43,-34.74,;21.1,-35.51,;21.1,-37.05,;19.77,-37.82,;18.43,-37.05,;18.42,-35.51,;19.76,-34.74,;17.1,-37.83,;17.1,-39.38,;15.76,-40.15,;15.77,-41.69,;14.43,-42.45,;14.43,-43.99,;15.76,-44.76,;15.76,-46.3,;17.1,-43.99,;17.1,-42.45,;18.43,-41.68,;14.43,-39.38,;13.1,-40.16,;11.76,-39.38,;11.76,-37.84,;10.43,-37.07,;13.1,-37.07,;13.1,-35.53,;11.77,-34.77,;10.44,-35.54,;11.77,-33.23,;13.11,-32.46,;14.44,-33.23,;14.44,-34.77,;15.77,-35.54,;14.43,-37.84,;15.76,-37.06,;23.76,-35.51,;25.1,-34.74,;23.76,-37.05,)| Show InChI InChI=1S/C29H24Cl3FN2O3/c1-16(29(37)38)34-11-9-17(10-12-34)18-13-22(20-6-5-19(33)15-25(20)32)21-7-8-27(36)35(26(21)14-18)28-23(30)3-2-4-24(28)31/h2-8,13-17H,9-12H2,1H3,(H,37,38)/t16-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck & Co.
Curated by ChEMBL
| Assay Description Inhibition of P38 alpha MAPK |
Bioorg Med Chem Lett 16: 64-8 (2005)
Article DOI: 10.1016/j.bmcl.2005.09.065 BindingDB Entry DOI: 10.7270/Q2TT4QH8 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50175757
((2S)-2-(4-(5-(2-chloro-4-fluorophenyl)-1-(2,6-dich...)Show SMILES C[C@H](N1CCC(CC1)c1cc(-c2ccc(F)cc2Cl)c2ccc(=O)n(-c3c(Cl)cccc3Cl)c2c1)C(O)=O |wU:1.0,(22.43,-33.2,;22.43,-34.74,;21.1,-35.51,;21.1,-37.05,;19.77,-37.82,;18.43,-37.05,;18.42,-35.51,;19.76,-34.74,;17.1,-37.83,;17.1,-39.38,;15.76,-40.15,;15.77,-41.69,;14.43,-42.45,;14.43,-43.99,;15.76,-44.76,;15.76,-46.3,;17.1,-43.99,;17.1,-42.45,;18.43,-41.68,;14.43,-39.38,;13.1,-40.16,;11.76,-39.38,;11.76,-37.84,;10.43,-37.07,;13.1,-37.07,;13.1,-35.53,;11.77,-34.77,;10.44,-35.54,;11.77,-33.23,;13.11,-32.46,;14.44,-33.23,;14.44,-34.77,;15.77,-35.54,;14.43,-37.84,;15.76,-37.06,;23.76,-35.51,;25.1,-34.74,;23.76,-37.05,)| Show InChI InChI=1S/C29H24Cl3FN2O3/c1-16(29(37)38)34-11-9-17(10-12-34)18-13-22(20-6-5-19(33)15-25(20)32)21-7-8-27(36)35(26(21)14-18)28-23(30)3-2-4-24(28)31/h2-8,13-17H,9-12H2,1H3,(H,37,38)/t16-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck & Co.
Curated by ChEMBL
| Assay Description Inhibition of TNF alpha release in THP1 cells |
Bioorg Med Chem Lett 16: 64-8 (2005)
Article DOI: 10.1016/j.bmcl.2005.09.065 BindingDB Entry DOI: 10.7270/Q2TT4QH8 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50175757
((2S)-2-(4-(5-(2-chloro-4-fluorophenyl)-1-(2,6-dich...)Show SMILES C[C@H](N1CCC(CC1)c1cc(-c2ccc(F)cc2Cl)c2ccc(=O)n(-c3c(Cl)cccc3Cl)c2c1)C(O)=O |wU:1.0,(22.43,-33.2,;22.43,-34.74,;21.1,-35.51,;21.1,-37.05,;19.77,-37.82,;18.43,-37.05,;18.42,-35.51,;19.76,-34.74,;17.1,-37.83,;17.1,-39.38,;15.76,-40.15,;15.77,-41.69,;14.43,-42.45,;14.43,-43.99,;15.76,-44.76,;15.76,-46.3,;17.1,-43.99,;17.1,-42.45,;18.43,-41.68,;14.43,-39.38,;13.1,-40.16,;11.76,-39.38,;11.76,-37.84,;10.43,-37.07,;13.1,-37.07,;13.1,-35.53,;11.77,-34.77,;10.44,-35.54,;11.77,-33.23,;13.11,-32.46,;14.44,-33.23,;14.44,-34.77,;15.77,-35.54,;14.43,-37.84,;15.76,-37.06,;23.76,-35.51,;25.1,-34.74,;23.76,-37.05,)| Show InChI InChI=1S/C29H24Cl3FN2O3/c1-16(29(37)38)34-11-9-17(10-12-34)18-13-22(20-6-5-19(33)15-25(20)32)21-7-8-27(36)35(26(21)14-18)28-23(30)3-2-4-24(28)31/h2-8,13-17H,9-12H2,1H3,(H,37,38)/t16-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 28 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck & Co.
Curated by ChEMBL
| Assay Description Inhibition of LPS stimulated TNF alpha release in whole blood |
Bioorg Med Chem Lett 16: 64-8 (2005)
Article DOI: 10.1016/j.bmcl.2005.09.065 BindingDB Entry DOI: 10.7270/Q2TT4QH8 |
More data for this Ligand-Target Pair | |