Found 2 hits Enz. Inhib. hit(s) with Target = 'Mitogen-activated protein kinase 14' and Ligand = 'BDBM50352571' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50352571
(CHEMBL1825152)Show SMILES Cc1ccc(cc1-c1ccc2c(NC(=O)[C@]22CC[C@H](O)CC2)c1)C(=O)NC1CC1 |r,wU:18.20,wD:15.15,(14.49,-15.14,;15.83,-15.9,;17.16,-15.12,;18.5,-15.89,;18.51,-17.43,;17.18,-18.2,;15.84,-17.44,;14.51,-18.21,;14.52,-19.76,;13.18,-20.53,;11.85,-19.76,;11.85,-18.22,;10.39,-17.74,;9.48,-18.99,;7.94,-18.98,;10.38,-20.23,;8.89,-20.63,;8.49,-22.11,;9.58,-23.21,;9.17,-24.69,;11.07,-22.81,;11.48,-21.32,;13.18,-17.44,;19.84,-18.2,;19.85,-19.74,;21.17,-17.42,;22.51,-18.19,;23.29,-19.52,;24.05,-18.18,)| Show InChI InChI=1S/C24H26N2O3/c1-14-2-3-16(22(28)25-17-5-6-17)12-19(14)15-4-7-20-21(13-15)26-23(29)24(20)10-8-18(27)9-11-24/h2-4,7,12-13,17-18,27H,5-6,8-11H2,1H3,(H,25,28)(H,26,29)/t18-,24- | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description Inhibition of human p38alpha using biotinylated ATF2 substrate by FRET assay |
Bioorg Med Chem Lett 21: 5270-3 (2011)
Article DOI: 10.1016/j.bmcl.2011.07.033 BindingDB Entry DOI: 10.7270/Q2KD1Z8K |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50352571
(CHEMBL1825152)Show SMILES Cc1ccc(cc1-c1ccc2c(NC(=O)[C@]22CC[C@H](O)CC2)c1)C(=O)NC1CC1 |r,wU:18.20,wD:15.15,(14.49,-15.14,;15.83,-15.9,;17.16,-15.12,;18.5,-15.89,;18.51,-17.43,;17.18,-18.2,;15.84,-17.44,;14.51,-18.21,;14.52,-19.76,;13.18,-20.53,;11.85,-19.76,;11.85,-18.22,;10.39,-17.74,;9.48,-18.99,;7.94,-18.98,;10.38,-20.23,;8.89,-20.63,;8.49,-22.11,;9.58,-23.21,;9.17,-24.69,;11.07,-22.81,;11.48,-21.32,;13.18,-17.44,;19.84,-18.2,;19.85,-19.74,;21.17,-17.42,;22.51,-18.19,;23.29,-19.52,;24.05,-18.18,)| Show InChI InChI=1S/C24H26N2O3/c1-14-2-3-16(22(28)25-17-5-6-17)12-19(14)15-4-7-20-21(13-15)26-23(29)24(20)10-8-18(27)9-11-24/h2-4,7,12-13,17-18,27H,5-6,8-11H2,1H3,(H,25,28)(H,26,29)/t18-,24- | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description Inhibition of p38alpha in human whole blood assessed as reduction in TNF-alpha production by ELISA |
Bioorg Med Chem Lett 21: 5270-3 (2011)
Article DOI: 10.1016/j.bmcl.2011.07.033 BindingDB Entry DOI: 10.7270/Q2KD1Z8K |
More data for this Ligand-Target Pair | |