Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mitogen-activated protein kinase kinase kinase 5 (Homo sapiens (Human)) | BDBM443127 (US10654833, Compound 1) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 5.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Hepatikos Therapeutics, LLC US Patent | Assay Description Compound binding to the ASK1 kinase active site was determined using the KINOMEscan Assay platform (DiscoverX, San Diego, Calif.). Briefly, ASK1-tagg... | US Patent US10654833 (2020) BindingDB Entry DOI: 10.7270/Q2F192R3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase kinase kinase 5 (Homo sapiens (Human)) | BDBM443127 (US10654833, Compound 1) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 5.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Hepatikos Therapeutics, LLC US Patent | Assay Description Inhibition of ASK1 kinase activity was determined radiometrically using 33P substrate incorporation (Reaction Biology Corp., Malvern, Pa.). Briefly, ... | US Patent US10654833 (2020) BindingDB Entry DOI: 10.7270/Q2F192R3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase kinase kinase 5 (Homo sapiens (Human)) | BDBM443127 (US10654833, Compound 1) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | 0.75 | n/a | n/a | n/a | n/a | n/a |
Hepatikos Therapeutics, LLC US Patent | Assay Description Compound binding to the ASK1 kinase active site was determined using the KINOMEscan Assay platform (DiscoverX, San Diego, Calif.). Briefly, ASK1-tagg... | US Patent US10654833 (2020) BindingDB Entry DOI: 10.7270/Q2F192R3 | |||||||||||
More data for this Ligand-Target Pair |