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Found 1 hit Enz. Inhib. hit(s) with Target = 'Monoglyceride lipase' and Ligand = 'BDBM50459633'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Monoglyceride lipase


(Homo sapiens (Human))		BDBM50459633
PNG
(CHEMBL4205134)
Show SMILES Clc1cccc(c1)-c1cccc(c1)N1CC(CC1=O)N1CCN(CC1)C(=O)c1nccs1
Show InChI InChI=1S/C24H23ClN4O2S/c25-19-5-1-3-17(13-19)18-4-2-6-20(14-18)29-16-21(15-22(29)30)27-8-10-28(11-9-27)24(31)23-26-7-12-32-23/h1-7,12-14,21H,8-11,15-16H2
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PC cid
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Article
PubMed
n/an/a 2.20n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of His-tagged human MAGL expressed in Escherichia coli BL21(DE3) assessed as reduction in arachidonic acid production from 2-arachidonoylg...

J Med Chem 61: 9205-9217 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00824
BindingDB Entry DOI: 10.7270/Q2FR008T
More data for this
Ligand-Target Pair