Compile Data Set for Download or QSAR

Found 4 hits Enz. Inhib. hit(s) with Target = 'Mucosa-associated lymphoid tissue lymphoma translocation protein 1' and Ligand = 'BDBM355921'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (Homo sapiens (Human))	BDBM355921 ((R)-1-(5-chloro-6- (2H-1,2,3-triazol-2- yl)pyridin...) Show SMILES COC[C@H](C)c1c(NC(=O)Nc2cnc(c(Cl)c2)-n2nccn2)cnc2cc(Cl)nn12 |r| Show InChI InChI=1S/C18H17Cl2N9O2/c1-10(9-31-2)16-13(8-21-15-6-14(20)27-28(15)16)26-18(30)25-11-5-12(19)17(22-7-11)29-23-3-4-24-29/h3-8,10H,9H2,1-2H3,(H2,25,26,30)/t10-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.00300	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...				US Patent US9815842 (2017) BindingDB Entry DOI: 10.7270/Q24F1T0N
					More data for this Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (Homo sapiens (Human))	BDBM355921 ((R)-1-(5-chloro-6- (2H-1,2,3-triazol-2- yl)pyridin...) Show SMILES COC[C@H](C)c1c(NC(=O)Nc2cnc(c(Cl)c2)-n2nccn2)cnc2cc(Cl)nn12 |r| Show InChI InChI=1S/C18H17Cl2N9O2/c1-10(9-31-2)16-13(8-21-15-6-14(20)27-28(15)16)26-18(30)25-11-5-12(19)17(22-7-11)29-23-3-4-24-29/h3-8,10H,9H2,1-2H3,(H2,25,26,30)/t10-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of MALT1 (unknown origin) using Ac-Trp-Leu-Arg-Ser-Arg^Cys(PT14)-NH2 as substrate preincubated for 60 mins followed by substrate addition ...				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01246 BindingDB Entry DOI: 10.7270/Q2DZ0CZ3
					More data for this Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (Homo sapiens (Human))	BDBM355921 ((R)-1-(5-chloro-6- (2H-1,2,3-triazol-2- yl)pyridin...) Show SMILES COC[C@H](C)c1c(NC(=O)Nc2cnc(c(Cl)c2)-n2nccn2)cnc2cc(Cl)nn12 |r| Show InChI InChI=1S/C18H17Cl2N9O2/c1-10(9-31-2)16-13(8-21-15-6-14(20)27-28(15)16)26-18(30)25-11-5-12(19)17(22-7-11)29-23-3-4-24-29/h3-8,10H,9H2,1-2H3,(H2,25,26,30)/t10-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	60	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of MALT1 in PMA-stimulated human Jurkat T cells assessed as reduction in IL2 level pretreated for 30 mins followed by PMA-stimulation meas...				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01246 BindingDB Entry DOI: 10.7270/Q2DZ0CZ3
					More data for this Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (Homo sapiens (Human))	BDBM355921 ((R)-1-(5-chloro-6- (2H-1,2,3-triazol-2- yl)pyridin...) Show SMILES COC[C@H](C)c1c(NC(=O)Nc2cnc(c(Cl)c2)-n2nccn2)cnc2cc(Cl)nn12 |r| Show InChI InChI=1S/C18H17Cl2N9O2/c1-10(9-31-2)16-13(8-21-15-6-14(20)27-28(15)16)26-18(30)25-11-5-12(19)17(22-7-11)29-23-3-4-24-29/h3-8,10H,9H2,1-2H3,(H2,25,26,30)/t10-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of MALT1 in human whole blood assessed as reduction in PMA//anti-CD28 antibody-induced IL2 level pre-incubated for 1 hrs before stimulatio...				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01246 BindingDB Entry DOI: 10.7270/Q2DZ0CZ3
					More data for this Ligand-Target Pair