Compile Data Set for Download or QSAR

Found 4 hits Enz. Inhib. hit(s) with Target = 'Mucosa-associated lymphoid tissue lymphoma translocation protein 1' and Ligand = 'BDBM355934'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (Homo sapiens (Human))	BDBM355934 (1-(5-chloro-6-(2H- 1,2,3-triazol-2- yl)pyridin-3-y...) Show SMILES Clc1cc2ncc(NC(=O)Nc3cnc(c(Cl)c3)-n3nccn3)c(C3CCOCC3)n2n1 Show InChI InChI=1S/C19H17Cl2N9O2/c20-13-7-12(9-23-18(13)30-24-3-4-25-30)26-19(31)27-14-10-22-16-8-15(21)28-29(16)17(14)11-1-5-32-6-2-11/h3-4,7-11H,1-2,5-6H2,(H2,26,27,31)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.00900	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...				US Patent US9815842 (2017) BindingDB Entry DOI: 10.7270/Q24F1T0N
					More data for this Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (Homo sapiens (Human))	BDBM355934 (1-(5-chloro-6-(2H- 1,2,3-triazol-2- yl)pyridin-3-y...) Show SMILES Clc1cc2ncc(NC(=O)Nc3cnc(c(Cl)c3)-n3nccn3)c(C3CCOCC3)n2n1 Show InChI InChI=1S/C19H17Cl2N9O2/c20-13-7-12(9-23-18(13)30-24-3-4-25-30)26-19(31)27-14-10-22-16-8-15(21)28-29(16)17(14)11-1-5-32-6-2-11/h3-4,7-11H,1-2,5-6H2,(H2,26,27,31)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of MALT1 (unknown origin) using Ac-Trp-Leu-Arg-Ser-Arg^Cys(PT14)-NH2 as substrate preincubated for 60 mins followed by substrate addition ...				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01246 BindingDB Entry DOI: 10.7270/Q2DZ0CZ3
					More data for this Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (Homo sapiens (Human))	BDBM355934 (1-(5-chloro-6-(2H- 1,2,3-triazol-2- yl)pyridin-3-y...) Show SMILES Clc1cc2ncc(NC(=O)Nc3cnc(c(Cl)c3)-n3nccn3)c(C3CCOCC3)n2n1 Show InChI InChI=1S/C19H17Cl2N9O2/c20-13-7-12(9-23-18(13)30-24-3-4-25-30)26-19(31)27-14-10-22-16-8-15(21)28-29(16)17(14)11-1-5-32-6-2-11/h3-4,7-11H,1-2,5-6H2,(H2,26,27,31)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	350	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of MALT1 in PMA-stimulated human Jurkat T cells assessed as reduction in IL2 level pretreated for 30 mins followed by PMA-stimulation meas...				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01246 BindingDB Entry DOI: 10.7270/Q2DZ0CZ3
					More data for this Ligand-Target Pair
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (Homo sapiens (Human))	BDBM355934 (1-(5-chloro-6-(2H- 1,2,3-triazol-2- yl)pyridin-3-y...) Show SMILES Clc1cc2ncc(NC(=O)Nc3cnc(c(Cl)c3)-n3nccn3)c(C3CCOCC3)n2n1 Show InChI InChI=1S/C19H17Cl2N9O2/c20-13-7-12(9-23-18(13)30-24-3-4-25-30)26-19(31)27-14-10-22-16-8-15(21)28-29(16)17(14)11-1-5-32-6-2-11/h3-4,7-11H,1-2,5-6H2,(H2,26,27,31)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of MALT1 in human whole blood assessed as reduction in PMA//anti-CD28 antibody-induced IL2 level pre-incubated for 1 hrs before stimulatio...				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01246 BindingDB Entry DOI: 10.7270/Q2DZ0CZ3
					More data for this Ligand-Target Pair