Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (Homo sapiens (Human)) | BDBM50510284 (CHEMBL4461333 | US10711036, Compound 101) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Cornell University; Dana-Farber Cancer Institute, Inc.; Children''s Medical Center Corporation US Patent | Assay Description For exemplary compounds of the disclosure, Ki for inhibition of MALT1 was measured (Table E11). A concentration of 100 nM MALT1 was used for the assa... | US Patent US10711036 (2020) BindingDB Entry DOI: 10.7270/Q2H70JVH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (Homo sapiens (Human)) | BDBM50510284 (CHEMBL4461333 | US10711036, Compound 101) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School Curated by ChEMBL | Assay Description Inhibition of recombinant LZ-fused MALT1 (340 to 789 residues) (unknown origin) using Ac-LRSR-AMC as substrate by fluorescence assay | Bioorg Med Chem Lett 29: 1336-1339 (2019) Article DOI: 10.1016/j.bmcl.2019.03.046 BindingDB Entry DOI: 10.7270/Q2WW7N1M | |||||||||||
More data for this Ligand-Target Pair |