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Found 1 hit Enz. Inhib. hit(s) with Target = 'Muscarinic acetylcholine receptor M4' and Ligand = 'BDBM50423966'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Muscarinic acetylcholine receptor M4


(Homo sapiens (Human))		BDBM50423966
PNG
(CHEMBL2313378)
Show SMILES CC(NC(=O)c1sc2nc(C)c(Cl)c(C)c2c1N)c1ccncc1
Show InChI InChI=1S/C17H17ClN4OS/c1-8-12-14(19)15(24-17(12)22-10(3)13(8)18)16(23)21-9(2)11-4-6-20-7-5-11/h4-7,9H,19H2,1-3H3,(H,21,23)
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Article
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n/an/an/an/a 600n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human muscarinic M4 receptor expressed in CHO-K1 cells assessed as leftward shift in acetylcholine response treated...

Bioorg Med Chem Lett 23: 346-50 (2012)


Article DOI: 10.1016/j.bmcl.2012.10.073
BindingDB Entry DOI: 10.7270/Q2N29Z8S
More data for this
Ligand-Target Pair