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Found 1 hit Enz. Inhib. hit(s) with Target = 'N-lysine methyltransferase SMYD2' and Ligand = 'BDBM50519304'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
N-lysine methyltransferase SMYD2


(Homo sapiens (Human))		BDBM50519304
PNG
(CHEMBL4440677)
Show SMILES CC(C)N1CCN(Cc2cc(nn2C)C(=O)N2CC(C2)n2cnc3c(N)ncnc23)CC1
Show InChI InChI=1S/C21H30N10O/c1-14(2)29-6-4-28(5-7-29)9-15-8-17(26-27(15)3)21(32)30-10-16(11-30)31-13-25-18-19(22)23-12-24-20(18)31/h8,12-14,16H,4-7,9-11H2,1-3H3,(H2,22,23,24)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 760n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human SMYD2 (1 to 433 residues) expressed in baculovirus infected Sf9 insect cells using biotinylated-p53 peptide (361 to 3...

J Med Chem 62: 7669-7683 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00112
BindingDB Entry DOI: 10.7270/Q2R78JK4
More data for this
Ligand-Target Pair