Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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NAD-dependent protein deacetylase sirtuin-1 (Homo sapiens (Human)) | BDBM50336799 (5,5',5''-[1,3,6-naphthalenetriyltris(sulfonylimino...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibition of recombinant SIRT1 using ZMAL substrate after 4 hrs by homogeneous fluorescence assay | ACS Med Chem Lett 3: 1050-1053 (2012) Article DOI: 10.1021/ml3002709 BindingDB Entry DOI: 10.7270/Q29C6ZKP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
NAD-dependent protein deacetylase sirtuin-1 (Homo sapiens (Human)) | BDBM50336799 (5,5',5''-[1,3,6-naphthalenetriyltris(sulfonylimino...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
Sirtris a GSK Company Curated by ChEMBL | Assay Description Inhibition of human GST-tagged SIRT1 expressed in Escherichia coli BL21(DE3) assessed as inhibition of ZMAL conversion to ZML after 4 hrs by fluoresc... | J Med Chem 56: 3666-79 (2013) Article DOI: 10.1021/jm400204k BindingDB Entry DOI: 10.7270/Q2D50P9C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
NAD-dependent protein deacetylase sirtuin-1 (Homo sapiens (Human)) | BDBM50336799 (5,5',5''-[1,3,6-naphthalenetriyltris(sulfonylimino...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 600 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute Curated by ChEMBL | Assay Description Inhibition of human full length SIRT1 expressed in DE3 cells by fluorimetric assay | Bioorg Med Chem 17: 7031-41 (2009) Article DOI: 10.1016/j.bmc.2009.07.073 BindingDB Entry DOI: 10.7270/Q21V5FWG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
NAD-dependent protein deacetylase sirtuin-1 (Homo sapiens (Human)) | BDBM50336799 (5,5',5''-[1,3,6-naphthalenetriyltris(sulfonylimino...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 2.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Hyderabad Campus Curated by ChEMBL | Assay Description Inhibition of full length recombinant human SIRT1 expressed in Escherichia coli BL21 (DE3) PLysS using Fluor-de-Lys as substrate by fluorimetric assa... | Bioorg Med Chem Lett 22: 6160-5 (2012) Article DOI: 10.1016/j.bmcl.2012.08.017 BindingDB Entry DOI: 10.7270/Q2CV4JWF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
NAD-dependent protein deacetylase sirtuin-1 (Homo sapiens (Human)) | BDBM50336799 (5,5',5''-[1,3,6-naphthalenetriyltris(sulfonylimino...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars | US Patent | n/a | n/a | 2.62E+3 | n/a | n/a | n/a | n/a | 8.0 | n/a |
Ikerchem, S.L.; Universidad del Pais Vasco US Patent | Assay Description 50 uM of substrate peptide (acetylated AMC-labeled peptide from p53 residues 379-382, RHKKAc, BioMol. Cat. #KI-177), 91 nM of human SIRT1 (full lengt... | US Patent US8835659 (2014) BindingDB Entry DOI: 10.7270/Q29K48ZN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
NAD-dependent protein deacetylase sirtuin-1 (Homo sapiens (Human)) | BDBM50336799 (5,5',5''-[1,3,6-naphthalenetriyltris(sulfonylimino...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 2.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Birla Institute of Technology and Science Curated by ChEMBL | Assay Description Inhibition of human SIRT1 using Fluor-de-Lys as substrate | Bioorg Med Chem Lett 22: 3256-60 (2012) Article DOI: 10.1016/j.bmcl.2012.03.030 BindingDB Entry DOI: 10.7270/Q26Q1Z88 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
NAD-dependent protein deacetylase sirtuin-1 (Homo sapiens (Human)) | BDBM50336799 (5,5',5''-[1,3,6-naphthalenetriyltris(sulfonylimino...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 2.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Technology Karnataka Curated by ChEMBL | Assay Description Inhibition of SIRT1 (unknown origin) using AMC-Arg-His-Lys-Lys(Ac) substrate assessed as deacetylation of substrate by fluorimetric enzyme assay | Bioorg Med Chem Lett 25: 2768-72 (2015) Article DOI: 10.1016/j.bmcl.2015.05.015 BindingDB Entry DOI: 10.7270/Q21V5GQN | |||||||||||
More data for this Ligand-Target Pair |