Found 5 hits Enz. Inhib. hit(s) with Target = 'NAD-dependent protein deacylase sirtuin-5, mitochondrial' and Ligand = 'BDBM50255722' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
NAD-dependent protein deacylase sirtuin-5, mitochondrial
(Homo sapiens (Human)) | BDBM50255722
(CHEMBL4063885)Show SMILES C[C@@H](O)[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CCCCNC(=S)CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CCCCN)[C@@H](C)O)C(=O)NCC(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(O)=O |r| Show InChI InChI=1S/C54H97N19O19S/c1-27(65-52(90)43(30(4)76)73-49(87)35(16-17-37(58)77)69-45(83)31(57)12-5-8-20-55)44(82)68-34(15-11-23-62-54(59)60)47(85)70-33(14-7-10-22-61-40(93)18-19-41(80)81)48(86)71-36(26-74)50(88)72-42(29(3)75)51(89)64-24-38(78)63-25-39(79)67-32(13-6-9-21-56)46(84)66-28(2)53(91)92/h27-36,42-43,74-76H,5-26,55-57H2,1-4H3,(H2,58,77)(H,61,93)(H,63,78)(H,64,89)(H,65,90)(H,66,84)(H,67,79)(H,68,82)(H,69,83)(H,70,85)(H,71,86)(H,72,88)(H,73,87)(H,80,81)(H,91,92)(H4,59,60,62)/t27-,28-,29+,30+,31-,32-,33-,34-,35-,36-,42-,43-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Department of Enzymology, Institute of Biochemistry and Biotechnology , Martin-Luther-University Halle-Wittenberg , 06120 Halle/Saale , Germany.
Curated by ChEMBL
| Assay Description
Inhibition of human SIRT5 using H3K9 succinyl peptide as substrate after 5 mins by HPLC method |
J Med Chem 61: 2460-2471 (2018)
Article DOI: 10.1021/acs.jmedchem.7b01648
BindingDB Entry DOI: 10.7270/Q2WW7M4J |
More data for this
Ligand-Target Pair | |
NAD-dependent protein deacylase sirtuin-5, mitochondrial
(Homo sapiens (Human)) | BDBM50255722
(CHEMBL4063885)Show SMILES C[C@@H](O)[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CCCCNC(=S)CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CCCCN)[C@@H](C)O)C(=O)NCC(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(O)=O |r| Show InChI InChI=1S/C54H97N19O19S/c1-27(65-52(90)43(30(4)76)73-49(87)35(16-17-37(58)77)69-45(83)31(57)12-5-8-20-55)44(82)68-34(15-11-23-62-54(59)60)47(85)70-33(14-7-10-22-61-40(93)18-19-41(80)81)48(86)71-36(26-74)50(88)72-42(29(3)75)51(89)64-24-38(78)63-25-39(79)67-32(13-6-9-21-56)46(84)66-28(2)53(91)92/h27-36,42-43,74-76H,5-26,55-57H2,1-4H3,(H2,58,77)(H,61,93)(H,63,78)(H,64,89)(H,65,90)(H,66,84)(H,67,79)(H,68,82)(H,69,83)(H,70,85)(H,71,86)(H,72,88)(H,73,87)(H,80,81)(H,91,92)(H4,59,60,62)/t27-,28-,29+,30+,31-,32-,33-,34-,35-,36-,42-,43-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Sichuan University
Curated by ChEMBL
| Assay Description
Inhibition of sirtuin 5 (unknown origin) |
Eur J Med Chem 161: 48-77 (2019)
Article DOI: 10.1016/j.ejmech.2018.10.028
BindingDB Entry DOI: 10.7270/Q2W380VZ |
More data for this
Ligand-Target Pair | |
NAD-dependent protein deacylase sirtuin-5, mitochondrial
(Homo sapiens (Human)) | BDBM50255722
(CHEMBL4063885)Show SMILES C[C@@H](O)[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CCCCNC(=S)CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CCCCN)[C@@H](C)O)C(=O)NCC(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(O)=O |r| Show InChI InChI=1S/C54H97N19O19S/c1-27(65-52(90)43(30(4)76)73-49(87)35(16-17-37(58)77)69-45(83)31(57)12-5-8-20-55)44(82)68-34(15-11-23-62-54(59)60)47(85)70-33(14-7-10-22-61-40(93)18-19-41(80)81)48(86)71-36(26-74)50(88)72-42(29(3)75)51(89)64-24-38(78)63-25-39(79)67-32(13-6-9-21-56)46(84)66-28(2)53(91)92/h27-36,42-43,74-76H,5-26,55-57H2,1-4H3,(H2,58,77)(H,61,93)(H,63,78)(H,64,89)(H,65,90)(H,66,84)(H,67,79)(H,68,82)(H,69,83)(H,70,85)(H,71,86)(H,72,88)(H,73,87)(H,80,81)(H,91,92)(H4,59,60,62)/t27-,28-,29+,30+,31-,32-,33-,34-,35-,36-,42-,43-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.ejmech.2022.114363
BindingDB Entry DOI: 10.7270/Q26W9G30 |
More data for this
Ligand-Target Pair | |
NAD-dependent protein deacylase sirtuin-5, mitochondrial
(Homo sapiens (Human)) | BDBM50255722
(CHEMBL4063885)Show SMILES C[C@@H](O)[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CCCCNC(=S)CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CCCCN)[C@@H](C)O)C(=O)NCC(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(O)=O |r| Show InChI InChI=1S/C54H97N19O19S/c1-27(65-52(90)43(30(4)76)73-49(87)35(16-17-37(58)77)69-45(83)31(57)12-5-8-20-55)44(82)68-34(15-11-23-62-54(59)60)47(85)70-33(14-7-10-22-61-40(93)18-19-41(80)81)48(86)71-36(26-74)50(88)72-42(29(3)75)51(89)64-24-38(78)63-25-39(79)67-32(13-6-9-21-56)46(84)66-28(2)53(91)92/h27-36,42-43,74-76H,5-26,55-57H2,1-4H3,(H2,58,77)(H,61,93)(H,63,78)(H,64,89)(H,65,90)(H,66,84)(H,67,79)(H,68,82)(H,69,83)(H,70,85)(H,71,86)(H,72,88)(H,73,87)(H,80,81)(H,91,92)(H4,59,60,62)/t27-,28-,29+,30+,31-,32-,33-,34-,35-,36-,42-,43-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00687
BindingDB Entry DOI: 10.7270/Q2125XQ3 |
More data for this
Ligand-Target Pair | |
NAD-dependent protein deacylase sirtuin-5, mitochondrial
(Homo sapiens (Human)) | BDBM50255722
(CHEMBL4063885)Show SMILES C[C@@H](O)[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CCCCNC(=S)CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CCCCN)[C@@H](C)O)C(=O)NCC(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(O)=O |r| Show InChI InChI=1S/C54H97N19O19S/c1-27(65-52(90)43(30(4)76)73-49(87)35(16-17-37(58)77)69-45(83)31(57)12-5-8-20-55)44(82)68-34(15-11-23-62-54(59)60)47(85)70-33(14-7-10-22-61-40(93)18-19-41(80)81)48(86)71-36(26-74)50(88)72-42(29(3)75)51(89)64-24-38(78)63-25-39(79)67-32(13-6-9-21-56)46(84)66-28(2)53(91)92/h27-36,42-43,74-76H,5-26,55-57H2,1-4H3,(H2,58,77)(H,61,93)(H,63,78)(H,64,89)(H,65,90)(H,66,84)(H,67,79)(H,68,82)(H,69,83)(H,70,85)(H,71,86)(H,72,88)(H,73,87)(H,80,81)(H,91,92)(H4,59,60,62)/t27-,28-,29+,30+,31-,32-,33-,34-,35-,36-,42-,43-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of SIRT5 (unknown origin) using KQTAR(SuK)STGGKA as substrate in presence of NAD |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113803
BindingDB Entry DOI: 10.7270/Q2XG9VZ4 |
More data for this
Ligand-Target Pair | |
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