Compile Data Set for Download or QSAR

Found 4 hits Enz. Inhib. hit(s) with Target = 'Neprilysin' and Ligand = 'BDBM50017733'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Neprilysin (Oryctolagus cuniculus (rabbit))	BDBM50017733 ((2S,4S)-2-Benzyl-4-(2-carboxy-ethylcarbamoyl)-5-ph...) Show SMILES OC(=O)CCNC(=O)[C@@H](C[C@@H](Cc1ccccc1)C(O)=O)Cc1ccccc1 Show InChI InChI=1S/C22H25NO5/c24-20(25)11-12-23-21(26)18(13-16-7-3-1-4-8-16)15-19(22(27)28)14-17-9-5-2-6-10-17/h1-10,18-19H,11-15H2,(H,23,26)(H,24,25)(H,27,28)/t18-,19-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
CIBA-GEIGY Corporation Curated by ChEMBL					Assay Description Inhibitory activity against Enkephalinase from rabbit using method 2 is determined.				J Med Chem 32: 2519-26 (1989) BindingDB Entry DOI: 10.7270/Q2668DSV
					More data for this Ligand-Target Pair
Neprilysin (Rattus norvegicus (Rat))	BDBM50017733 ((2S,4S)-2-Benzyl-4-(2-carboxy-ethylcarbamoyl)-5-ph...) Show SMILES OC(=O)CCNC(=O)[C@@H](C[C@@H](Cc1ccccc1)C(O)=O)Cc1ccccc1 Show InChI InChI=1S/C22H25NO5/c24-20(25)11-12-23-21(26)18(13-16-7-3-1-4-8-16)15-19(22(27)28)14-17-9-5-2-6-10-17/h1-10,18-19H,11-15H2,(H,23,26)(H,24,25)(H,27,28)/t18-,19-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
CIBA-GEIGY Corporation Curated by ChEMBL					Assay Description Inhibition of enkephalinase activity in synaptic membranes prepared from rat striatum				J Med Chem 32: 2519-26 (1989) BindingDB Entry DOI: 10.7270/Q2668DSV
					More data for this Ligand-Target Pair
Neprilysin (Rattus norvegicus (Rat))	BDBM50017733 ((2S,4S)-2-Benzyl-4-(2-carboxy-ethylcarbamoyl)-5-ph...) Show SMILES OC(=O)CCNC(=O)[C@@H](C[C@@H](Cc1ccccc1)C(O)=O)Cc1ccccc1 Show InChI InChI=1S/C22H25NO5/c24-20(25)11-12-23-21(26)18(13-16-7-3-1-4-8-16)15-19(22(27)28)14-17-9-5-2-6-10-17/h1-10,18-19H,11-15H2,(H,23,26)(H,24,25)(H,27,28)/t18-,19-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
CIBA-GEIGY Corporation Curated by ChEMBL					Assay Description The compound was tested in vitro for inhibition of Neutral endopeptidase by using Leu enkephalin as substrate				J Med Chem 38: 1689-700 (1995) BindingDB Entry DOI: 10.7270/Q2Z89BD0
					More data for this Ligand-Target Pair
Neprilysin (Rattus norvegicus (Rat))	BDBM50017733 ((2S,4S)-2-Benzyl-4-(2-carboxy-ethylcarbamoyl)-5-ph...) Show SMILES OC(=O)CCNC(=O)[C@@H](C[C@@H](Cc1ccccc1)C(O)=O)Cc1ccccc1 Show InChI InChI=1S/C22H25NO5/c24-20(25)11-12-23-21(26)18(13-16-7-3-1-4-8-16)15-19(22(27)28)14-17-9-5-2-6-10-17/h1-10,18-19H,11-15H2,(H,23,26)(H,24,25)(H,27,28)/t18-,19-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
CIBA-GEIGY Corporation Curated by ChEMBL					Assay Description The compound was tested for inhibition of Neutral endopeptidase by using GAAP as substrate				J Med Chem 38: 1689-700 (1995) BindingDB Entry DOI: 10.7270/Q2Z89BD0
					More data for this Ligand-Target Pair