Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Neurogenic locus notch homolog protein 1/Recombining binding protein suppressor of hairless' and Ligand = 'BDBM242877'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Neurogenic locus notch homolog protein 1/Recombining binding protein suppressor of hairless (Homo sapiens (Human))	BDBM242877 (US9427442, 5) Show SMILES NC(=O)[C@H]([C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2ccccc2)c2cccc(Cl)c2NC1=O)C1CCC(F)(F)CC1 |r,t:15| Show InChI InChI=1S/C28H28ClF5N4O3/c29-19-8-4-7-18-21(16-5-2-1-3-6-16)36-24(26(41)37-22(18)19)38-25(40)17(11-14-28(32,33)34)20(23(35)39)15-9-12-27(30,31)13-10-15/h1-8,15,17,20,24H,9-14H2,(H2,35,39)(H,37,41)(H,38,40)/t17-,20+,24-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.40	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description The Notch-CBF1 (C-promoter binding factor I) cell based transactivation assay is based on the ability of the released Notch intracellular domain frag...				US Patent US9427442 (2016) BindingDB Entry DOI: 10.7270/Q2ZP452P
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