BindingDB PrimarySearch

Found 12 hits Enz. Inhib. hit(s) with Target = 'Neuromedin-K receptor' and Ligand = 'BDBM50112179'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Neuromedin-K receptor (Homo sapiens (Human))	BDBM50112179 (CHEMBL3608740 \| US10030025, Compound 20 \| US108367...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	50	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Euroscreen SA Curated by ChEMBL					Assay Description Binding affinity to human recombinant NK3R by radioligand binding assay				ACS Med Chem Lett 6: 736-40 (2015) Article DOI: 10.1021/acsmedchemlett.5b00117 BindingDB Entry DOI: 10.7270/Q2TQ639V
Euroscreen SA Curated by ChEMBL					More data for this Ligand-Target Pair
Neuromedin-K receptor (Homo sapiens (Human))	BDBM50112179 (CHEMBL3608740 \| US10030025, Compound 20 \| US108367...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars		60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details BindingDB Entry DOI: 10.7270/Q2348QHC
TBA					More data for this Ligand-Target Pair
Neuromedin-K receptor (Homo sapiens (Human))	BDBM50112179 (CHEMBL3608740 \| US10030025, Compound 20 \| US108367...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Ogeda SA US Patent					Assay Description The affinity of compounds of the invention for the human NK-3 receptor was determined by measuring the ability of compounds of the invention to compe...				US Patent US10836768 (2020) BindingDB Entry DOI: 10.7270/Q2Z03C74
Ogeda SA US Patent					More data for this Ligand-Target Pair
Neuromedin-K receptor (Homo sapiens (Human))	BDBM50112179 (CHEMBL3608740 \| US10030025, Compound 20 \| US108367...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
BioCryst Pharmaceuticals					Assay Description Human NK-3: The ability of compounds of the invention to inhibit the binding of the NK-3 receptor selective antagonist 3H-SB222200 was assessed by an...				Bioorg Med Chem 17: 3934-58 (2009) BindingDB Entry DOI: 10.7270/Q2SN0C9W
BioCryst Pharmaceuticals					More data for this Ligand-Target Pair
Neuromedin-K receptor (Homo sapiens (Human))	BDBM50112179 (CHEMBL3608740 \| US10030025, Compound 20 \| US108367...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	60	n/a	n/a	n/a	n/a	n/a	n/a	7.4	n/a
EUROSCREEN SA US Patent					Assay Description The affinity of compounds of the invention for the human NK-3 receptor was determined by measuring the ability of compounds of the invention to compe...				US Patent US9422299 (2016) BindingDB Entry DOI: 10.7270/Q2GM866C
EUROSCREEN SA US Patent					More data for this Ligand-Target Pair
Neuromedin-K receptor (Homo sapiens (Human))	BDBM50112179 (CHEMBL3608740 \| US10030025, Compound 20 \| US108367...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars		60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details BindingDB Entry DOI: 10.7270/Q2348QHC
TBA					More data for this Ligand-Target Pair
Neuromedin-K receptor (Homo sapiens (Human))	BDBM50112179 (CHEMBL3608740 \| US10030025, Compound 20 \| US108367...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	60	n/a	n/a	n/a	n/a	n/a	n/a	7.4	n/a
OGEDA SA US Patent					Assay Description The affinity of compounds of the invention for the human NK-3 receptor was determined by measuring the ability of compounds of the invention to compe...				US Patent US10030025 (2018) BindingDB Entry DOI: 10.7270/Q2B56MSG
OGEDA SA US Patent					More data for this Ligand-Target Pair
Neuromedin-K receptor (Rattus norvegicus)	BDBM50112179 (CHEMBL3608740 \| US10030025, Compound 20 \| US108367...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	573	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Euroscreen SA Curated by ChEMBL					Assay Description Binding affinity to rat NK3R				ACS Med Chem Lett 6: 736-40 (2015) Article DOI: 10.1021/acsmedchemlett.5b00117 BindingDB Entry DOI: 10.7270/Q2TQ639V
Euroscreen SA Curated by ChEMBL					More data for this Ligand-Target Pair
Neuromedin-K receptor (Homo sapiens (Human))	BDBM50112179 (CHEMBL3608740 \| US10030025, Compound 20 \| US108367...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	63	n/a	n/a	n/a	n/a	n/a	n/a
Euroscreen SA Curated by ChEMBL					Assay Description Antagonist activity against human recombinant NK3R expressed in CHO cells by aequorin functional assay				ACS Med Chem Lett 6: 736-40 (2015) Article DOI: 10.1021/acsmedchemlett.5b00117 BindingDB Entry DOI: 10.7270/Q2TQ639V
Euroscreen SA Curated by ChEMBL					More data for this Ligand-Target Pair
Neuromedin-K receptor (Homo sapiens (Human))	BDBM50112179 (CHEMBL3608740 \| US10030025, Compound 20 \| US108367...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	93	n/a	n/a	n/a	n/a	n/a	n/a
Ogeda SA US Patent					Assay Description Changes in intracellular calcium levels are a recognized indicator of G protein-coupled receptor activity. The efficacy of compounds of the invention...				US Patent US10836768 (2020) BindingDB Entry DOI: 10.7270/Q2Z03C74
Ogeda SA US Patent					More data for this Ligand-Target Pair
Neuromedin-K receptor (Homo sapiens (Human))	BDBM50112179 (CHEMBL3608740 \| US10030025, Compound 20 \| US108367...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	93	n/a	n/a	n/a	n/a	n/a	n/a
EUROSCREEN SA US Patent					Assay Description Chinese Hamster Ovary recombinant cells expressing the human NK-3 receptor and a construct that encodes the photoprotein apoaequorin were used for th...				US Patent US9422299 (2016) BindingDB Entry DOI: 10.7270/Q2GM866C
EUROSCREEN SA US Patent					More data for this Ligand-Target Pair
Neuromedin-K receptor (Homo sapiens (Human))	BDBM50112179 (CHEMBL3608740 \| US10030025, Compound 20 \| US108367...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	93	n/a	n/a	n/a	n/a	n/a	n/a
OGEDA SA US Patent					Assay Description Changes in intracellular calcium levels are a recognized indicator of G protein-coupled receptor activity. The efficacy of compounds of the invention...				US Patent US10030025 (2018) BindingDB Entry DOI: 10.7270/Q2B56MSG
OGEDA SA US Patent					More data for this Ligand-Target Pair