Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Neuronal acetylcholine receptor subunit alpha-4/beta-2 (Rattus norvegicus (Rat)) | BDBM50049756 (3-((S)-1-Methyl-pyrrolidin-2-ylmethoxy)-pyridine |...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 0.150 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories Curated by ChEMBL | Assay Description Nicotinic acetylcholine receptor binding activity was determined by ability of the compound to displace [3H]- (-) cytisine binding from whole rat bra... | Bioorg Med Chem Lett 9: 2747-52 (1999) BindingDB Entry DOI: 10.7270/Q20Z72HG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuronal acetylcholine receptor subunit alpha-4/beta-2 (Rattus norvegicus (Rat)) | BDBM50049756 (3-((S)-1-Methyl-pyrrolidin-2-ylmethoxy)-pyridine |...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 0.150 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories Curated by ChEMBL | Assay Description Binding affinity towards nAChR (alpha4-beta2) by the displacement of [3H]-(-)-cytisine in whole rat brain membranes. | Bioorg Med Chem Lett 8: 249-54 (1999) BindingDB Entry DOI: 10.7270/Q2P26X90 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuronal acetylcholine receptor subunit alpha-4/beta-2 (Rattus norvegicus (Rat)) | BDBM50049756 (3-((S)-1-Methyl-pyrrolidin-2-ylmethoxy)-pyridine |...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 0.150 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Milano Curated by ChEMBL | Assay Description Displacement of [3H]-cytisine from alpha4beta2-nACHR in rat whole brain | Bioorg Med Chem Lett 26: 5613-5617 (2016) Article DOI: 10.1016/j.bmcl.2016.10.078 BindingDB Entry DOI: 10.7270/Q2RJ4MFR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuronal acetylcholine receptor subunit alpha-4/beta-2 (Rattus norvegicus (Rat)) | BDBM50049756 (3-((S)-1-Methyl-pyrrolidin-2-ylmethoxy)-pyridine |...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 0.150 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories Curated by ChEMBL | Assay Description In vitro ability to displace [3H]-(-)-cytisine binding to whole rat brain membranes at Nicotinic acetylcholine receptor alpha4-beta2 | Bioorg Med Chem Lett 11: 631-3 (2001) BindingDB Entry DOI: 10.7270/Q2WM1CPS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuronal acetylcholine receptor subunit alpha-4/beta-2 (Rattus norvegicus (Rat)) | BDBM50049756 (3-((S)-1-Methyl-pyrrolidin-2-ylmethoxy)-pyridine |...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 1.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Illinois at Chicago Curated by ChEMBL | Assay Description Inhibition of [3H]epibatidine binding to rat Nicotinic acetylcholine receptor alpha4-beta2 | J Med Chem 48: 1721-4 (2005) Article DOI: 10.1021/jm0492406 BindingDB Entry DOI: 10.7270/Q2BZ65JW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuronal acetylcholine receptor subunit alpha-4/beta-2 (Homo sapiens (Human)) | BDBM50049756 (3-((S)-1-Methyl-pyrrolidin-2-ylmethoxy)-pyridine |...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article | n/a | n/a | n/a | n/a | 750 | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Tested for functional activity against neuronal nicotinic acetylcholine receptor(nAChR) expressed in K177 cells using isotopic rubidium efflux assay. | Bioorg Med Chem Lett 7: 2703-2708 (1997) Article DOI: 10.1016/S0960-894X(97)10080-4 BindingDB Entry DOI: 10.7270/Q2Z60P30 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuronal acetylcholine receptor subunit alpha-4/beta-2 (Homo sapiens (Human)) | BDBM50049756 (3-((S)-1-Methyl-pyrrolidin-2-ylmethoxy)-pyridine |...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | n/a | n/a | 750 | n/a | n/a | n/a | n/a |
Abbott Laboratories Curated by ChEMBL | Assay Description Binding affinity towards nAChR (alpha4-beta2) by the displacement of [3H]-(-)-cytisine in whole rat brain membranes. | Bioorg Med Chem Lett 8: 249-54 (1999) BindingDB Entry DOI: 10.7270/Q2P26X90 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuronal acetylcholine receptor subunit alpha-4/beta-2 (Homo sapiens (Human)) | BDBM50049756 (3-((S)-1-Methyl-pyrrolidin-2-ylmethoxy)-pyridine |...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 750 | n/a | n/a | n/a | n/a |
Abbott Laboratories Curated by ChEMBL | Assay Description Binding affinity against Nicotinic Acetylcholine Receptor was determined by measuring the displacement of [3H]-cytisine from a preparation of whole r... | J Med Chem 40: 4169-94 (1998) Article DOI: 10.1021/jm970377o BindingDB Entry DOI: 10.7270/Q2QF8TH9 | |||||||||||
More data for this Ligand-Target Pair |