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Found 1 hit Enz. Inhib. hit(s) with Target = 'Neutrophil elastase' and Ligand = 'BDBM50015891'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Neutrophil elastase


(Homo sapiens (Human))		BDBM50015891
PNG
(3-Acetoxymethyl-7-butoxy-5,5,8-trioxo-5lambda*6*-t...)
Show SMILES CCCCO[C@@H]1[C@@H]2N(C1=O)C(C(=O)OC(C)(C)C)=C(COC(C)=O)CS2(=O)=O |t:18|
Show InChI InChI=1S/C18H27NO8S/c1-6-7-8-25-14-15(21)19-13(17(22)27-18(3,4)5)12(9-26-11(2)20)10-28(23,24)16(14)19/h14,16H,6-10H2,1-5H3/t14-,16+/m0/s1
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PubMed
n/an/a>4.00E+4n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibitory concentration which is required to cause 50% inhibition of human leukocyte elastase (HLE) enzyme

J Med Chem 33: 2513-21 (1990)


BindingDB Entry DOI: 10.7270/Q2Q81C2Q
More data for this
Ligand-Target Pair