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Found 1 hit Enz. Inhib. hit(s) with Target = 'Neutrophil elastase' and Ligand = 'BDBM50023517'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Neutrophil elastase


(Homo sapiens (Human))		BDBM50023517
PNG
(2,2-Dimethyl-propionic acid 5-(2,2-dimethyl-propio...)
Show SMILES CC(C)(C)C(=O)Oc1ccc(cc1)C(=O)c1ccc(OC(=O)C(C)(C)C)cc1OC(=O)C(C)(C)C
Show InChI InChI=1S/C28H34O7/c1-26(2,3)23(30)33-18-12-10-17(11-13-18)22(29)20-15-14-19(34-24(31)27(4,5)6)16-21(20)35-25(32)28(7,8)9/h10-16H,1-9H3
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n/an/a 55n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity against human leukocyte elastase at 10e-5 M

J Med Chem 31: 1052-61 (1988)


BindingDB Entry DOI: 10.7270/Q2PC31DJ
More data for this
Ligand-Target Pair