Compile Data Set for Download or QSAR

Found 3 hits Enz. Inhib. hit(s) with Target = 'Nicotinamide phosphoribosyltransferase' and Ligand = 'BDBM50060825'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM50060825 (CHEMBL3394722 | US10696692, Example 213) Show SMILES O=C(NCc1ccc(cc1)S(=O)(=O)C1CCN(CC1)C1CCOCC1)c1cc2cnccc2[nH]1 Show InChI InChI=1S/C25H30N4O4S/c30-25(24-15-19-17-26-10-5-23(19)28-24)27-16-18-1-3-21(4-2-18)34(31,32)22-6-11-29(12-7-22)20-8-13-33-14-9-20/h1-5,10,15,17,20,22,28H,6-9,11-14,16H2,(H,27,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Inc. Curated by ChEMBL					Assay Description Inhibition of human C-terminal His6-tagged NAMPT expressed in Escherichia coli Rosetta(DE3) incubated for 15 mins prior to substrate addition measure...				Bioorg Med Chem Lett 25: 529-41 (2015) Article DOI: 10.1016/j.bmcl.2014.12.026 BindingDB Entry DOI: 10.7270/Q2736SK7
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM50060825 (CHEMBL3394722 | US10696692, Example 213) Show SMILES O=C(NCc1ccc(cc1)S(=O)(=O)C1CCN(CC1)C1CCOCC1)c1cc2cnccc2[nH]1 Show InChI InChI=1S/C25H30N4O4S/c30-25(24-15-19-17-26-10-5-23(19)28-24)27-16-18-1-3-21(4-2-18)34(31,32)22-6-11-29(12-7-22)20-8-13-33-14-9-20/h1-5,10,15,17,20,22,28H,6-9,11-14,16H2,(H,27,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	20.7	n/a	n/a	n/a	n/a	n/a	n/a
TBA US Patent					Assay Description The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...				US Patent US10696692 (2020) BindingDB Entry DOI: 10.7270/Q29W0JHQ
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM50060825 (CHEMBL3394722 | US10696692, Example 213) Show SMILES O=C(NCc1ccc(cc1)S(=O)(=O)C1CCN(CC1)C1CCOCC1)c1cc2cnccc2[nH]1 Show InChI InChI=1S/C25H30N4O4S/c30-25(24-15-19-17-26-10-5-23(19)28-24)27-16-18-1-3-21(4-2-18)34(31,32)22-6-11-29(12-7-22)20-8-13-33-14-9-20/h1-5,10,15,17,20,22,28H,6-9,11-14,16H2,(H,27,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	20.7	n/a	n/a	n/a	n/a	n/a	n/a
TBA US Patent					Assay Description The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...				US Patent US10696692 (2020) BindingDB Entry DOI: 10.7270/Q29W0JHQ
					More data for this Ligand-Target Pair