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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Nicotinamide phosphoribosyltransferase' and Ligand = 'BDBM50241442'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))		BDBM50241442
PNG
(CHEMBL4092869)
Show SMILES Nc1ccccc1NC(=O)c1ccc(NC(=S)NCc2cccnc2)cc1
Show InChI InChI=1S/C20H19N5OS/c21-17-5-1-2-6-18(17)25-19(26)15-7-9-16(10-8-15)24-20(27)23-13-14-4-3-11-22-12-14/h1-12H,13,21H2,(H,25,26)(H2,23,24,27)
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Article
PubMed
n/an/a 116n/an/an/an/an/an/a



Second Military Medical University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant NAMPT using NAM as substrate preincubated for 5 mins followed by substrate addition measured after 15 mins by fluores...

J Med Chem 60: 7965-7983 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00467
BindingDB Entry DOI: 10.7270/Q2VM4FDV
More data for this
Ligand-Target Pair