Compile Data Set for Download or QSAR

Found 4 hits Enz. Inhib. hit(s) with Target = 'Non-receptor tyrosine-protein kinase TYK2' and Ligand = 'BDBM329948'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM329948 (US10463675, Example 31 | US10980815, Ex. No. 31 | ...) Show SMILES CNC(=O)c1ncc(Nc2nccc(n2)N2C[C@@H]3CC[C@H](C2)N3C(=O)[C@@H]2C[C@H]2C#N)cc1Cl |r,THB:23:22:15.16.21:19.18| Show InChI InChI=1S/C22H23ClN8O2/c1-25-20(32)19-17(23)7-13(9-27-19)28-22-26-5-4-18(29-22)30-10-14-2-3-15(11-30)31(14)21(33)16-6-12(16)8-24/h4-5,7,9,12,14-16H,2-3,6,10-11H2,1H3,(H,25,32)(H,26,28,29)/t12-,14-,15+,16+/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	32	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description Compounds were added to a 384-well plate. Reaction mixtures contained 10 mM HEPES, pH 7.4, 10 mM MgCl2, 0.01% BSA, 0.0005% Tween 20, 1 mM ATP and 1 &...				US Patent US9663526 (2017) BindingDB Entry DOI: 10.7270/Q2CV4KVD
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM329948 (US10463675, Example 31 | US10980815, Ex. No. 31 | ...) Show SMILES CNC(=O)c1ncc(Nc2nccc(n2)N2C[C@@H]3CC[C@H](C2)N3C(=O)[C@@H]2C[C@H]2C#N)cc1Cl |r,THB:23:22:15.16.21:19.18| Show InChI InChI=1S/C22H23ClN8O2/c1-25-20(32)19-17(23)7-13(9-27-19)28-22-26-5-4-18(29-22)30-10-14-2-3-15(11-30)31(14)21(33)16-6-12(16)8-24/h4-5,7,9,12,14-16H,2-3,6,10-11H2,1H3,(H,25,32)(H,26,28,29)/t12-,14-,15+,16+/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	32	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Compounds were added to a 384-well plate. Reaction mixtures contained 10 mM HEPES, pH 7.4, 10 mM MgCl2, 0.01% BSA, 0.0005% Tween 20, 1 mM ATP and 1 M...				Citation and Details BindingDB Entry DOI: 10.7270/Q2PC35J0
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM329948 (US10463675, Example 31 | US10980815, Ex. No. 31 | ...) Show SMILES CNC(=O)c1ncc(Nc2nccc(n2)N2C[C@@H]3CC[C@H](C2)N3C(=O)[C@@H]2C[C@H]2C#N)cc1Cl |r,THB:23:22:15.16.21:19.18| Show InChI InChI=1S/C22H23ClN8O2/c1-25-20(32)19-17(23)7-13(9-27-19)28-22-26-5-4-18(29-22)30-10-14-2-3-15(11-30)31(14)21(33)16-6-12(16)8-24/h4-5,7,9,12,14-16H,2-3,6,10-11H2,1H3,(H,25,32)(H,26,28,29)/t12-,14-,15+,16+/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	32	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description Compounds were added to a 384-well plate. Reaction mixtures contained 10 mM HEPES, pH 7.4, 10 mM MgCl2, 0.01% BSA, 0.0005% Tween 20, 1 mM ATP and 1 &...				US Patent US10980815 (2021) BindingDB Entry DOI: 10.7270/Q2XD14SG
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM329948 (US10463675, Example 31 | US10980815, Ex. No. 31 | ...) Show SMILES CNC(=O)c1ncc(Nc2nccc(n2)N2C[C@@H]3CC[C@H](C2)N3C(=O)[C@@H]2C[C@H]2C#N)cc1Cl |r,THB:23:22:15.16.21:19.18| Show InChI InChI=1S/C22H23ClN8O2/c1-25-20(32)19-17(23)7-13(9-27-19)28-22-26-5-4-18(29-22)30-10-14-2-3-15(11-30)31(14)21(33)16-6-12(16)8-24/h4-5,7,9,12,14-16H,2-3,6,10-11H2,1H3,(H,25,32)(H,26,28,29)/t12-,14-,15+,16+/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	32	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description Compounds were added to a 384-well plate. Reaction mixtures contained 10 mM HEPES, pH 7.4, 10 mM MgCl2, 0.01% BSA, 0.0005% Tween 20, 1 mM ATP and 1 &...				US Patent US10463675 (2019) BindingDB Entry DOI: 10.7270/Q2VT1VGN
					More data for this Ligand-Target Pair