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Found 1 hit Enz. Inhib. hit(s) with Target = 'Non-receptor tyrosine-protein kinase TYK2 [V731I]' and Ligand = 'BDBM399615'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Non-receptor tyrosine-protein kinase TYK2 [V731I]


(Homo sapiens (Human))		BDBM399615
PNG
(US10323036, Compound I-59 | US10793574, Compound I...)
Show SMILES COc1c(Nc2cc(Nc3ccc(cn3)C3CC3)nc3[nH]n(C)c(=O)c23)cccc1-c1nnn(C)n1
Show InChI InChI=1S/C24H24N10O2/c1-33-24(35)20-17(26-16-6-4-5-15(21(16)36-3)22-29-32-34(2)31-22)11-19(28-23(20)30-33)27-18-10-9-14(12-25-18)13-7-8-13/h4-6,9-13H,7-8H2,1-3H3,(H3,25,26,27,28,30)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/a 0.300n/an/an/an/an/a



Novartis Institute for Tropical Diseases



Assay Description
Binding constants for compounds of the present invention against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Di...

Anal Biochem 395: 195-204 (2009)


BindingDB Entry DOI: 10.7270/Q2X63Q9X
More data for this
Ligand-Target Pair