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Found 1 hit Enz. Inhib. hit(s) with Target = 'Nuclear factor NF-kappa-B p105 subunit' and Ligand = 'BDBM446448'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Nuclear factor NF-kappa-B p105 subunit


(Homo sapiens (Human))		BDBM446448
PNG
((R)-1-((7-cyano-2-(3′-(7-((3-hydroxypyrrolid...)
Show SMILES Cc1nc(Nc2cccc(c2C)-c2cccc(-c3nc4cc(CN5CCC(CC5)C(O)=O)cc(C#N)c4o3)c2C)c2ncc(CN3CC[C@@H](O)C3)cc2n1 |r|
Show InChI InChI=1S/C42H42N8O4/c1-24-32(6-4-8-34(24)41-48-37-17-27(16-30(19-43)39(37)54-41)21-49-13-10-29(11-14-49)42(52)53)33-7-5-9-35(25(33)2)47-40-38-36(45-26(3)46-40)18-28(20-44-38)22-50-15-12-31(51)23-50/h4-9,16-18,20,29,31,51H,10-15,21-23H2,1-3H3,(H,52,53)(H,45,46,47)/t31-/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 55n/an/an/an/a



Incyte Corporation

US Patent


Assay Description
PD-L1 aAPC/CHO-Klcells (Promega) were maintained in F-12 medium with addition of 10% FBS, 200 μg/ml Hygromycin B, 250 μg/ml Geneticin (G418...

US Patent US10669271 (2020)


BindingDB Entry DOI: 10.7270/Q2MG7SJC
More data for this
Ligand-Target Pair