BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Nuclear factor NF-kappa-B p105 subunit' and Ligand = 'BDBM446458'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Nuclear factor NF-kappa-B p105 subunit


(Homo sapiens (Human))		BDBM446458
PNG
((R)-1-((7-cyano-2-(3′-(7-(((R)-3-hydroxypyrr...)
Show SMILES Cc1nc(Nc2cccc(c2C)-c2cccc(-c3nc4cc(CN5CC[C@](C)(C5)C(O)=O)cc(C#N)c4o3)c2C)c2ncc(CN3CC[C@@H](O)C3)cc2n1 |r|
Show InChI InChI=1S/C42H42N8O4/c1-24-31(7-5-9-33(24)40-48-36-16-27(15-29(18-43)38(36)54-40)20-50-14-12-42(4,23-50)41(52)53)32-8-6-10-34(25(32)2)47-39-37-35(45-26(3)46-39)17-28(19-44-37)21-49-13-11-30(51)22-49/h5-10,15-17,19,30,51H,11-14,20-23H2,1-4H3,(H,52,53)(H,45,46,47)/t30-,42-/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 55n/an/an/an/a



Incyte Corporation

US Patent


Assay Description
PD-L1 aAPC/CHO-Klcells (Promega) were maintained in F-12 medium with addition of 10% FBS, 200 μg/ml Hygromycin B, 250 μg/ml Geneticin (G418...

US Patent US10669271 (2020)


BindingDB Entry DOI: 10.7270/Q2MG7SJC
More data for this
Ligand-Target Pair