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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Nuclear factor NF-kappa-B p105 subunit' and Ligand = 'BDBM446461'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Nuclear factor NF-kappa-B p105 subunit


(Homo sapiens (Human))		BDBM446461
PNG
((R)-1-((7-cyano-2-(3′-(7-(((S)-1-hydroxyprop...)
Show SMILES C[C@@H](CO)NCc1cnc2c(Nc3cccc(c3C)-c3cccc(-c4nc5cc(CN6CC[C@](C)(C6)C(O)=O)cc(C#N)c5o4)c3C)nc(C)nc2c1 |r|
Show InChI InChI=1S/C41H42N8O4/c1-23(21-50)43-18-28-16-34-36(44-19-28)38(46-26(4)45-34)47-33-11-7-9-31(25(33)3)30-8-6-10-32(24(30)2)39-48-35-15-27(14-29(17-42)37(35)53-39)20-49-13-12-41(5,22-49)40(51)52/h6-11,14-16,19,23,43,50H,12-13,18,20-22H2,1-5H3,(H,51,52)(H,45,46,47)/t23-,41+/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 55n/an/an/an/a



Incyte Corporation

US Patent


Assay Description
PD-L1 aAPC/CHO-Klcells (Promega) were maintained in F-12 medium with addition of 10% FBS, 200 μg/ml Hygromycin B, 250 μg/ml Geneticin (G418...

US Patent US10669271 (2020)


BindingDB Entry DOI: 10.7270/Q2MG7SJC
More data for this
Ligand-Target Pair