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Found 1 hit Enz. Inhib. hit(s) with Target = 'Nuclear factor NF-kappa-B p105 subunit' and Ligand = 'BDBM446470'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Nuclear factor NF-kappa-B p105 subunit


(Homo sapiens (Human))		BDBM446470
PNG
((S)-1-((7-cyano-2-(3′-(2-(difluoromethyl)-7-...)
Show SMILES Cc1c(Nc2nc(nc3cc(CN4CC[C@@H](O)C4)cnc23)C(F)F)cccc1-c1cccc(-c2nc3cc(CN4CC[C@@](C)(C4)C(O)=O)cc(C#N)c3o2)c1C |r|
Show InChI InChI=1S/C42H40F2N8O4/c1-23-29(6-4-8-31(23)40-49-34-15-25(14-27(17-45)36(34)56-40)19-52-13-11-42(3,22-52)41(54)55)30-7-5-9-32(24(30)2)47-38-35-33(48-39(50-38)37(43)44)16-26(18-46-35)20-51-12-10-28(53)21-51/h4-9,14-16,18,28,37,53H,10-13,19-22H2,1-3H3,(H,54,55)(H,47,48,50)/t28-,42+/m1/s1
PDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<10n/an/an/an/a



Incyte Corporation

US Patent


Assay Description
PD-L1 aAPC/CHO-Klcells (Promega) were maintained in F-12 medium with addition of 10% FBS, 200 μg/ml Hygromycin B, 250 μg/ml Geneticin (G418...

US Patent US10669271 (2020)


BindingDB Entry DOI: 10.7270/Q2MG7SJC
More data for this
Ligand-Target Pair