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Found 1 hit Enz. Inhib. hit(s) with Target = 'Nuclear factor NF-kappa-B p105 subunit' and Ligand = 'BDBM446472'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Nuclear factor NF-kappa-B p105 subunit


(Homo sapiens (Human))		BDBM446472
PNG
((R)-1-((7-cyano-2-(3′-(2-(difluoromethyl)-7-...)
Show SMILES CN(C)C(=O)C1CCN(Cc2cc(C#N)c3oc(nc3c2)-c2cccc(c2C)-c2cccc(Nc3nc(nc4cc(CN5CC[C@@H](O)C5)cnc34)C(F)F)c2C)CC1 |r|
Show InChI InChI=1S/C44H45F2N9O3/c1-25-32(7-5-9-34(25)43-51-37-18-27(17-30(20-47)39(37)58-43)22-54-14-11-29(12-15-54)44(57)53(3)4)33-8-6-10-35(26(33)2)49-41-38-36(50-42(52-41)40(45)46)19-28(21-48-38)23-55-16-13-31(56)24-55/h5-10,17-19,21,29,31,40,56H,11-16,22-24H2,1-4H3,(H,49,50,52)/t31-/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
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PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 55n/an/an/an/a



Incyte Corporation

US Patent


Assay Description
PD-L1 aAPC/CHO-Klcells (Promega) were maintained in F-12 medium with addition of 10% FBS, 200 μg/ml Hygromycin B, 250 μg/ml Geneticin (G418...

US Patent US10669271 (2020)


BindingDB Entry DOI: 10.7270/Q2MG7SJC
More data for this
Ligand-Target Pair