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Found 1 hit Enz. Inhib. hit(s) with Target = 'Nuclear factor NF-kappa-B p105 subunit' and Ligand = 'BDBM446474'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Nuclear factor NF-kappa-B p105 subunit


(Homo sapiens (Human))		BDBM446474
PNG
((R)-3-(1-((7-cyano-2-(3′-(2-(difluoromethyl)...)
Show SMILES Cc1c(Nc2nc(nc3cc(CN4CC[C@@H](O)C4)cnc23)C(F)F)cccc1-c1cccc(-c2nc3cc(CN4CCC(CC4)C(=O)NCCC(O)=O)cc(C#N)c3o2)c1C |r|
Show InChI InChI=1S/C45H45F2N9O5/c1-25-32(33-6-4-8-35(26(33)2)51-42-39-36(52-43(54-42)41(46)47)19-28(21-50-39)23-56-16-12-31(57)24-56)5-3-7-34(25)45-53-37-18-27(17-30(20-48)40(37)61-45)22-55-14-10-29(11-15-55)44(60)49-13-9-38(58)59/h3-8,17-19,21,29,31,41,57H,9-16,22-24H2,1-2H3,(H,49,60)(H,58,59)(H,51,52,54)/t31-/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
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PC cid
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UniChem
US Patent
n/an/an/an/a 55n/an/an/an/a



Incyte Corporation

US Patent


Assay Description
PD-L1 aAPC/CHO-Klcells (Promega) were maintained in F-12 medium with addition of 10% FBS, 200 μg/ml Hygromycin B, 250 μg/ml Geneticin (G418...

US Patent US10669271 (2020)


BindingDB Entry DOI: 10.7270/Q2MG7SJC
More data for this
Ligand-Target Pair