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Found 1 hit Enz. Inhib. hit(s) with Target = 'Nuclear factor NF-kappa-B p105 subunit' and Ligand = 'BDBM446476'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Nuclear factor NF-kappa-B p105 subunit


(Homo sapiens (Human))		BDBM446476
PNG
((R)-1-((2-(3′-(2-amino-7-((3-hydroxypyrrolid...)
Show SMILES Cc1c(Nc2nc(N)nc3cc(CN4CC[C@@H](O)C4)cnc23)cccc1-c1cccc(-c2nc3cc(CN4CCC(CC4)C(O)=O)cc(C#N)c3o2)c1C |r|
Show InChI InChI=1S/C41H41N9O4/c1-23-30(5-3-7-32(23)39-46-35-16-25(15-28(18-42)37(35)54-39)20-49-12-9-27(10-13-49)40(52)53)31-6-4-8-33(24(31)2)45-38-36-34(47-41(43)48-38)17-26(19-44-36)21-50-14-11-29(51)22-50/h3-8,15-17,19,27,29,51H,9-14,20-22H2,1-2H3,(H,52,53)(H3,43,45,47,48)/t29-/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 55n/an/an/an/a



Incyte Corporation

US Patent


Assay Description
PD-L1 aAPC/CHO-Klcells (Promega) were maintained in F-12 medium with addition of 10% FBS, 200 μg/ml Hygromycin B, 250 μg/ml Geneticin (G418...

US Patent US10669271 (2020)


BindingDB Entry DOI: 10.7270/Q2MG7SJC
More data for this
Ligand-Target Pair