BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Nuclear factor NF-kappa-B p105 subunit' and Ligand = 'BDBM446477'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Nuclear factor NF-kappa-B p105 subunit


(Homo sapiens (Human))		BDBM446477
PNG
((R)-1-((7-cyano-2-(3′-(2-(difluoromethyl)-7-...)
Show SMILES Cc1c(Nc2nc(nc3cc(CN4CC[C@@](C)(O)C4)cnc23)C(F)F)cccc1-c1cccc(-c2nc3cc(CN4CCC(CC4)C(O)=O)cc(C#N)c3o2)c1C |r|
Show InChI InChI=1S/C43H42F2N8O4/c1-24-30(6-4-8-32(24)41-50-35-17-26(16-29(19-46)37(35)57-41)21-52-13-10-28(11-14-52)42(54)55)31-7-5-9-33(25(31)2)48-39-36-34(49-40(51-39)38(44)45)18-27(20-47-36)22-53-15-12-43(3,56)23-53/h4-9,16-18,20,28,38,56H,10-15,21-23H2,1-3H3,(H,54,55)(H,48,49,51)/t43-/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<10n/an/an/an/a



Incyte Corporation

US Patent


Assay Description
PD-L1 aAPC/CHO-Klcells (Promega) were maintained in F-12 medium with addition of 10% FBS, 200 μg/ml Hygromycin B, 250 μg/ml Geneticin (G418...

US Patent US10669271 (2020)


BindingDB Entry DOI: 10.7270/Q2MG7SJC
More data for this
Ligand-Target Pair