Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Nuclear receptor subfamily 1 group I member 2 (Homo sapiens (Human)) | BDBM429620 (US10550091, No. LC-29 | US10947203, No. LC-29) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
St. Jude Children''s Research Hospital US Patent | Assay Description The time-resolved fluorescence resonance transfer (TR-FRET) hPXR competitive binding assay was performed according to the manufacturer's instruct... | US Patent US10550091 (2020) BindingDB Entry DOI: 10.7270/Q2NK3HFJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor subfamily 1 group I member 2 (Homo sapiens (Human)) | BDBM429620 (US10550091, No. LC-29 | US10947203, No. LC-29) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
ST. JUDE CHILDREN''S RSEARCH HOSPITAL US Patent | Assay Description The time-resolved fluorescence resonance transfer (TR-FRET) hPXR competitive binding assay was performed according to the manufacturer's instruct... | US Patent US10947203 (2021) BindingDB Entry DOI: 10.7270/Q2HM5CKJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor subfamily 1 group I member 2 (Homo sapiens (Human)) | BDBM429620 (US10550091, No. LC-29 | US10947203, No. LC-29) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 550 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Displacement of BODIPY FL vindoline from GST-tagged human PXR LBD incubated for 60 mins by TR-FRET assay | Citation and Details Article DOI: 10.1021/acs.jmedchem.0c02201 BindingDB Entry DOI: 10.7270/Q2KS6WBB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor subfamily 1 group I member 2 (Homo sapiens (Human)) | BDBM429620 (US10550091, No. LC-29 | US10947203, No. LC-29) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 600 | n/a | n/a | n/a | n/a |
TBA | Assay Description Agonist activity at human PXR expressed in HepG2 cells co-expressing luciferase gene under control of CYP3A4 promoter incubated for 24 hrs by lucifer... | Citation and Details Article DOI: 10.1021/acs.jmedchem.0c02201 BindingDB Entry DOI: 10.7270/Q2KS6WBB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor subfamily 1 group I member 2 (Homo sapiens (Human)) | BDBM429620 (US10550091, No. LC-29 | US10947203, No. LC-29) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 530 | n/a | n/a | n/a | n/a |
ST. JUDE CHILDREN''S RSEARCH HOSPITAL US Patent | Assay Description The hPXR transactivation assays (PXR agonistic and antagonistic assays) were performed in the HepG2 cells stably expressing FLAG-hPXR and CYP3A4-luci... | US Patent US10947203 (2021) BindingDB Entry DOI: 10.7270/Q2HM5CKJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor subfamily 1 group I member 2 (Homo sapiens (Human)) | BDBM429620 (US10550091, No. LC-29 | US10947203, No. LC-29) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 530 | n/a | n/a | n/a | n/a |
St. Jude Children''s Research Hospital US Patent | Assay Description The hPXR transactivation assays (PXR agonistic and antagonistic assays) were performed in the HepG2 cells stably expressing FLAG-hPXR and CYP3A4-luci... | US Patent US10550091 (2020) BindingDB Entry DOI: 10.7270/Q2NK3HFJ | |||||||||||
More data for this Ligand-Target Pair |