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Found 1 hit Enz. Inhib. hit(s) with Target = 'Oxidized purine nucleoside triphosphate hydrolase' and Ligand = 'BDBM50511429'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Oxidized purine nucleoside triphosphate hydrolase


(Homo sapiens (Human))		BDBM50511429
PNG
(CHEMBL4475123)
Show SMILES Nc1nc2c(N)ccc(-c3cccc(Cl)c3Cl)n2n1
Show InChI InChI=1S/C12H9Cl2N5/c13-7-3-1-2-6(10(7)14)9-5-4-8(15)11-17-12(16)18-19(9)11/h1-5H,15H2,(H2,16,18)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 207n/an/an/an/an/an/a



Gilead Sciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant human His-tagged MTH1 expressed in Escherichia coli BL21 (DE3) using 8-oxo-dGTP as substrate incubated for 15 mins fo...

ACS Med Chem Lett 11: 358-364 (2020)


Article DOI: 10.1021/acsmedchemlett.9b00420
BindingDB Entry DOI: 10.7270/Q2PV6PPZ
More data for this
Ligand-Target Pair