Compile Data Set for Download or QSAR

Found 10 hits Enz. Inhib. hit(s) with Target = 'P2X purinoceptor 7' and Ligand = 'BDBM160105'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
P2X purinoceptor 7 (Mus musculus)	BDBM160105 (US10047092, 46 | US10053463, 46 | US9040534, 46) Show SMILES C[C@H]1Cn2c(nnc2-c2cccc(C)n2)C(=O)N1Cc1cccc(c1Cl)C(F)(F)F |r| Show InChI InChI=1S/C20H17ClF3N5O/c1-11-5-3-8-15(25-11)17-26-27-18-19(30)28(12(2)9-29(17)18)10-13-6-4-7-14(16(13)21)20(22,23)24/h3-8,12H,9-10H2,1-2H3/t12-/m0/s1	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	12.6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description human or rat P2X7-1321N1 cells were collected and frozen @−80° C. On the day of the experiment, cell membrane preparations were made according ...				US Patent US10053463 (2018) BindingDB Entry DOI: 10.7270/Q2FT8P24
					More data for this Ligand-Target Pair
P2X purinoceptor 7 (Homo sapiens (Human))	BDBM160105 (US10047092, 46 | US10053463, 46 | US9040534, 46) Show SMILES C[C@H]1Cn2c(nnc2-c2cccc(C)n2)C(=O)N1Cc1cccc(c1Cl)C(F)(F)F |r| Show InChI InChI=1S/C20H17ClF3N5O/c1-11-5-3-8-15(25-11)17-26-27-18-19(30)28(12(2)9-29(17)18)10-13-6-4-7-14(16(13)21)20(22,23)24/h3-8,12H,9-10H2,1-2H3/t12-/m0/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	12.6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Radioligand binding: human or rat P2X7-1321N1 cells were collected and frozen @ −80° C. On the day of the experiment, cell membrane preparation...				US Patent US9040534 (2015) BindingDB Entry DOI: 10.7270/Q2JS9P6W
					More data for this Ligand-Target Pair
P2X purinoceptor 7 (Homo sapiens (Human))	BDBM160105 (US10047092, 46 | US10053463, 46 | US9040534, 46) Show SMILES C[C@H]1Cn2c(nnc2-c2cccc(C)n2)C(=O)N1Cc1cccc(c1Cl)C(F)(F)F |r| Show InChI InChI=1S/C20H17ClF3N5O/c1-11-5-3-8-15(25-11)17-26-27-18-19(30)28(12(2)9-29(17)18)10-13-6-4-7-14(16(13)21)20(22,23)24/h3-8,12H,9-10H2,1-2H3/t12-/m0/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	12.6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description human or rat P2X7-1321N1 cells were collected and frozen @−80° C. On the day of the experiment, cell membrane preparations were made according ...				US Patent US10053463 (2018) BindingDB Entry DOI: 10.7270/Q2FT8P24
					More data for this Ligand-Target Pair
P2X purinoceptor 7 (Homo sapiens (Human))	BDBM160105 (US10047092, 46 | US10053463, 46 | US9040534, 46) Show SMILES C[C@H]1Cn2c(nnc2-c2cccc(C)n2)C(=O)N1Cc1cccc(c1Cl)C(F)(F)F |r| Show InChI InChI=1S/C20H17ClF3N5O/c1-11-5-3-8-15(25-11)17-26-27-18-19(30)28(12(2)9-29(17)18)10-13-6-4-7-14(16(13)21)20(22,23)24/h3-8,12H,9-10H2,1-2H3/t12-/m0/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	12.6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description human or rat P2X7-1321N1 cells were collected and frozen @ −80° C. On the day of the experiment, cell membrane preparations were made according...				US Patent US10047092 (2018) BindingDB Entry DOI: 10.7270/Q27D2X4N
					More data for this Ligand-Target Pair
P2X purinoceptor 7 (Homo sapiens (Human))	BDBM160105 (US10047092, 46 | US10053463, 46 | US9040534, 46) Show SMILES C[C@H]1Cn2c(nnc2-c2cccc(C)n2)C(=O)N1Cc1cccc(c1Cl)C(F)(F)F |r| Show InChI InChI=1S/C20H17ClF3N5O/c1-11-5-3-8-15(25-11)17-26-27-18-19(30)28(12(2)9-29(17)18)10-13-6-4-7-14(16(13)21)20(22,23)24/h3-8,12H,9-10H2,1-2H3/t12-/m0/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.30	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Ca2+ Flux: 1321N1 cells expressing the recombinant human, rat or mouse P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium...				US Patent US9040534 (2015) BindingDB Entry DOI: 10.7270/Q2JS9P6W
					More data for this Ligand-Target Pair
P2X purinoceptor 7 (Homo sapiens (Human))	BDBM160105 (US10047092, 46 | US10053463, 46 | US9040534, 46) Show SMILES C[C@H]1Cn2c(nnc2-c2cccc(C)n2)C(=O)N1Cc1cccc(c1Cl)C(F)(F)F |r| Show InChI InChI=1S/C20H17ClF3N5O/c1-11-5-3-8-15(25-11)17-26-27-18-19(30)28(12(2)9-29(17)18)10-13-6-4-7-14(16(13)21)20(22,23)24/h3-8,12H,9-10H2,1-2H3/t12-/m0/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.30	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description 1321N1 cells expressing the recombinant human, rat or mouse P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high ...				US Patent US10047092 (2018) BindingDB Entry DOI: 10.7270/Q27D2X4N
					More data for this Ligand-Target Pair
P2X purinoceptor 7 (Homo sapiens (Human))	BDBM160105 (US10047092, 46 | US10053463, 46 | US9040534, 46) Show SMILES C[C@H]1Cn2c(nnc2-c2cccc(C)n2)C(=O)N1Cc1cccc(c1Cl)C(F)(F)F |r| Show InChI InChI=1S/C20H17ClF3N5O/c1-11-5-3-8-15(25-11)17-26-27-18-19(30)28(12(2)9-29(17)18)10-13-6-4-7-14(16(13)21)20(22,23)24/h3-8,12H,9-10H2,1-2H3/t12-/m0/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.30	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description 1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...				US Patent US10053463 (2018) BindingDB Entry DOI: 10.7270/Q2FT8P24
					More data for this Ligand-Target Pair
P2X purinoceptor 7 (Mus musculus)	BDBM160105 (US10047092, 46 | US10053463, 46 | US9040534, 46) Show SMILES C[C@H]1Cn2c(nnc2-c2cccc(C)n2)C(=O)N1Cc1cccc(c1Cl)C(F)(F)F |r| Show InChI InChI=1S/C20H17ClF3N5O/c1-11-5-3-8-15(25-11)17-26-27-18-19(30)28(12(2)9-29(17)18)10-13-6-4-7-14(16(13)21)20(22,23)24/h3-8,12H,9-10H2,1-2H3/t12-/m0/s1	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	154	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description 1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...				US Patent US10053463 (2018) BindingDB Entry DOI: 10.7270/Q2FT8P24
					More data for this Ligand-Target Pair
P2X purinoceptor 7 (Rattus norvegicus (Rat))	BDBM160105 (US10047092, 46 | US10053463, 46 | US9040534, 46) Show SMILES C[C@H]1Cn2c(nnc2-c2cccc(C)n2)C(=O)N1Cc1cccc(c1Cl)C(F)(F)F |r| Show InChI InChI=1S/C20H17ClF3N5O/c1-11-5-3-8-15(25-11)17-26-27-18-19(30)28(12(2)9-29(17)18)10-13-6-4-7-14(16(13)21)20(22,23)24/h3-8,12H,9-10H2,1-2H3/t12-/m0/s1	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	154	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description 1321N1 cells expressing the recombinant human, rat or mouse P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high ...				US Patent US10047092 (2018) BindingDB Entry DOI: 10.7270/Q27D2X4N
					More data for this Ligand-Target Pair
P2X purinoceptor 7 (Rattus norvegicus (Rat))	BDBM160105 (US10047092, 46 | US10053463, 46 | US9040534, 46) Show SMILES C[C@H]1Cn2c(nnc2-c2cccc(C)n2)C(=O)N1Cc1cccc(c1Cl)C(F)(F)F |r| Show InChI InChI=1S/C20H17ClF3N5O/c1-11-5-3-8-15(25-11)17-26-27-18-19(30)28(12(2)9-29(17)18)10-13-6-4-7-14(16(13)21)20(22,23)24/h3-8,12H,9-10H2,1-2H3/t12-/m0/s1	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	155	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Ca2+ Flux: 1321N1 cells expressing the recombinant human, rat or mouse P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium...				US Patent US9040534 (2015) BindingDB Entry DOI: 10.7270/Q2JS9P6W
					More data for this Ligand-Target Pair