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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Perforin-1' and Ligand = 'BDBM50276477'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Perforin-1


(Homo sapiens (Human))		BDBM50276477
PNG
(CHEMBL4174447)
Show SMILES CN1Cc2cc(ccc2C1=O)-c1ccc(s1)-c1cnc(F)c(NS(=O)(=O)c2ccccn2)c1
Show InChI InChI=1S/C23H17FN4O3S2/c1-28-13-16-10-14(5-6-17(16)23(28)29)19-7-8-20(32-19)15-11-18(22(24)26-12-15)27-33(30,31)21-4-2-3-9-25-21/h2-12,27H,13H2,1H3
NCI pathway
KEGG

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PC cid
PC sid
UniChem

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Similars
Article
PubMed
n/an/a 4.10E+3n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of perforin (unknown origin)-mediated 51Cr-labelled human Jurkat cell lysis preincubated with protein for 30 mins followed by cell additio...

Eur J Med Chem 137: 139-155 (2017)


Article DOI: 10.1016/j.ejmech.2017.05.048
BindingDB Entry DOI: 10.7270/Q21R6T15
More data for this
Ligand-Target Pair