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Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'Period circadian protein homolog 2' and Ligand = 'BDBM356979'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356979
PNG
((S)-1-((S)-3-(9H- carbazol-9-yl)-2- hydroxypropyl)...)
Show SMILES C[C@H]1CCC(=O)N(C[C@@H](O)Cn2c3ccccc3c3ccccc23)C1 |r|
Show InChI InChI=1S/C21H24N2O2/c1-15-10-11-21(25)22(12-15)13-16(24)14-23-19-8-4-2-6-17(19)18-7-3-5-9-20(18)23/h2-9,15-16,24H,10-14H2,1H3/t15-,16+/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 1.13E+3n/an/an/an/a



Synchronicity Pharma, Inc.

US Patent


Assay Description
In brief, stable U20S reporter cells harboring Per2-dLuc were plated at a density of 30,000 cells/well in Corning 96-well, solid white, flat bottom, ...


US Patent US10759777 (2020)


BindingDB Entry DOI: 10.7270/Q2C250HB
More data for this
Ligand-Target Pair
Period circadian protein homolog 2


(Homo sapiens (Human))
BDBM356979
PNG
((S)-1-((S)-3-(9H- carbazol-9-yl)-2- hydroxypropyl)...)
Show SMILES C[C@H]1CCC(=O)N(C[C@@H](O)Cn2c3ccccc3c3ccccc23)C1 |r|
Show InChI InChI=1S/C21H24N2O2/c1-15-10-11-21(25)22(12-15)13-16(24)14-23-19-8-4-2-6-17(19)18-7-3-5-9-20(18)23/h2-9,15-16,24H,10-14H2,1H3/t15-,16+/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 1.13E+3n/an/an/an/a



Reset Therapeutics, Inc.

US Patent


Assay Description
Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...


US Patent US10214507 (2019)


BindingDB Entry DOI: 10.7270/Q2KH0QMT
More data for this
Ligand-Target Pair