Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Peroxisome proliferator-activated receptor alpha (Homo sapiens (Human)) | BDBM28800 (2-{[(3-{[2-(4-chlorophenyl)-5-methyl-1,3-oxazol-4-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 260 | n/a | 10 | n/a | n/a | 8.0 | 22 |
Bristol-Myers Squibb Company | Assay Description For hPPAR alpha, percentage inhibition was calculated relative to unlabeled GW2331, which was used as the active site-specific competitive binder. Fl... | J Pharmacol Exp Ther 327: 716-26 (2008) Article DOI: 10.1124/jpet.108.143271 BindingDB Entry DOI: 10.7270/Q2VD6WT9 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Peroxisome proliferator-activated receptor alpha (Homo sapiens (Human)) | BDBM28800 (2-{[(3-{[2-(4-chlorophenyl)-5-methyl-1,3-oxazol-4-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 260 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Curated by ChEMBL | Assay Description Binding affinity to human His-tagged PPARalpha LBD (E196-Y468) expressed in Escherichia coli BL21 (DE3) by fluorescence polarization assay | J Med Chem 53: 2854-64 (2010) Article DOI: 10.1021/jm9016812 BindingDB Entry DOI: 10.7270/Q2B56JW0 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Peroxisome proliferator-activated receptor alpha (Rattus norvegicus) | BDBM28800 (2-{[(3-{[2-(4-chlorophenyl)-5-methyl-1,3-oxazol-4-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase MCE MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | n/a | n/a | n/a | n/a | 317 | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company | Assay Description EC50 is the concentration of test compounds needed to induce 50% of the maximum luciferase activity in HEK cells transfected with PPAR and Gal4-lucif... | J Pharmacol Exp Ther 327: 716-26 (2008) Article DOI: 10.1124/jpet.108.143271 BindingDB Entry DOI: 10.7270/Q2VD6WT9 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Peroxisome proliferator-activated receptor alpha (Mus musculus) | BDBM28800 (2-{[(3-{[2-(4-chlorophenyl)-5-methyl-1,3-oxazol-4-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase MCE MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | n/a | n/a | n/a | n/a | 426 | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company Curated by ChEMBL | Assay Description Agonist activity at mouse PPAR-alpha | ACS Med Chem Lett 7: 590-4 (2016) Article DOI: 10.1021/acsmedchemlett.6b00033 BindingDB Entry DOI: 10.7270/Q2CR5W99 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Peroxisome proliferator-activated receptor alpha (Mesocricetus auratus (golden hamster)) | BDBM28800 (2-{[(3-{[2-(4-chlorophenyl)-5-methyl-1,3-oxazol-4-...) | PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase MCE MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | n/a | n/a | n/a | n/a | 488 | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Curated by ChEMBL | Assay Description Agonist activity at syrian golden hamster PPARalpha LBD (167-468) expressed in HEK293 cells coexpressing GAL4-DBD by transactivation assay | J Med Chem 53: 2854-64 (2010) Article DOI: 10.1021/jm9016812 BindingDB Entry DOI: 10.7270/Q2B56JW0 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Peroxisome proliferator-activated receptor alpha (Homo sapiens (Human)) | BDBM28800 (2-{[(3-{[2-(4-chlorophenyl)-5-methyl-1,3-oxazol-4-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | n/a | n/a | 9.60 | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb R&D Curated by ChEMBL | Assay Description Agonist activity against human Gal4-fussed PPARalpha in HEK293 cells by luciferase reporter gene assay | Bioorg Med Chem Lett 20: 2933-7 (2010) Article DOI: 10.1016/j.bmcl.2010.03.019 BindingDB Entry DOI: 10.7270/Q2K35TS2 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Peroxisome proliferator-activated receptor alpha (Homo sapiens (Human)) | BDBM28800 (2-{[(3-{[2-(4-chlorophenyl)-5-methyl-1,3-oxazol-4-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | n/a | n/a | 10 | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Curated by ChEMBL | Assay Description Agonist activity at human PPARalpha LBD (167-468) expressed in HEK293 cells coexpressing GAL4-DBD by transactivation assay | J Med Chem 53: 2854-64 (2010) Article DOI: 10.1021/jm9016812 BindingDB Entry DOI: 10.7270/Q2B56JW0 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Peroxisome proliferator-activated receptor alpha (Homo sapiens (Human)) | BDBM28800 (2-{[(3-{[2-(4-chlorophenyl)-5-methyl-1,3-oxazol-4-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | n/a | n/a | 47 | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Curated by ChEMBL | Assay Description Agonist activity at full length human PPARalpha expressed in HepG2 cells cotransfected with pBL-tk-luciferase by luciferase reporter gene assay | J Med Chem 53: 2854-64 (2010) Article DOI: 10.1021/jm9016812 BindingDB Entry DOI: 10.7270/Q2B56JW0 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Peroxisome proliferator-activated receptor alpha (Mus musculus) | BDBM28800 (2-{[(3-{[2-(4-chlorophenyl)-5-methyl-1,3-oxazol-4-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase MCE MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | n/a | n/a | n/a | n/a | 426 | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Curated by ChEMBL | Assay Description Agonist activity at mouse PPARalpha LBD (167-469) expressed in HEK293 cells coexpressing GAL4-DBD by transactivation assay | J Med Chem 53: 2854-64 (2010) Article DOI: 10.1021/jm9016812 BindingDB Entry DOI: 10.7270/Q2B56JW0 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Peroxisome proliferator-activated receptor alpha (Mus musculus) | BDBM28800 (2-{[(3-{[2-(4-chlorophenyl)-5-methyl-1,3-oxazol-4-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase MCE MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | n/a | n/a | n/a | n/a | 426 | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company | Assay Description EC50 is the concentration of test compounds needed to induce 50% of the maximum luciferase activity in HEK cells transfected with PPAR and Gal4-lucif... | J Pharmacol Exp Ther 327: 716-26 (2008) Article DOI: 10.1124/jpet.108.143271 BindingDB Entry DOI: 10.7270/Q2VD6WT9 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Peroxisome proliferator-activated receptor alpha (Mesocricetus auratus (golden hamster)) | BDBM28800 (2-{[(3-{[2-(4-chlorophenyl)-5-methyl-1,3-oxazol-4-...) | PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase MCE MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | n/a | n/a | n/a | n/a | 488 | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company | Assay Description EC50 is the concentration of test compounds needed to induce 50% of the maximum luciferase activity in HEK cells transfected with PPAR and Gal4-lucif... | J Pharmacol Exp Ther 327: 716-26 (2008) Article DOI: 10.1124/jpet.108.143271 BindingDB Entry DOI: 10.7270/Q2VD6WT9 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Peroxisome proliferator-activated receptor alpha (Rattus norvegicus) | BDBM28800 (2-{[(3-{[2-(4-chlorophenyl)-5-methyl-1,3-oxazol-4-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase MCE MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | n/a | n/a | n/a | n/a | 317 | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company Curated by ChEMBL | Assay Description Agonist activity at rat PPAR-alpha | ACS Med Chem Lett 7: 590-4 (2016) Article DOI: 10.1021/acsmedchemlett.6b00033 BindingDB Entry DOI: 10.7270/Q2CR5W99 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |