BindingDB PrimarySearch

Found 13 hits Enz. Inhib. hit(s) with Target = 'Peroxisome proliferator-activated receptor alpha' and Ligand = 'BDBM50150998'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Peroxisome proliferator-activated receptor alpha (Homo sapiens (Human))	BDBM50150998 (((4-Methoxy-phenoxycarbonyl)-{4-[2-(5-methyl-2-phe...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	188	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Curated by ChEMBL					Assay Description Binding affinity at PPAR alpha receptor				Drug Metab Dispos 35: 150-67 (2006) Article DOI: 10.1124/dmd.106.012450 BindingDB Entry DOI: 10.7270/Q2JS9R92
Bristol-Myers Squibb Curated by ChEMBL					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (Homo sapiens (Human))	BDBM50150998 (((4-Methoxy-phenoxycarbonyl)-{4-[2-(5-methyl-2-phe...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	190	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb R&D Curated by ChEMBL					Assay Description Binding affinity at human PPARalpha by fluorescence polarization				Bioorg Med Chem Lett 18: 3545-50 (2008) Article DOI: 10.1016/j.bmcl.2008.05.014 BindingDB Entry DOI: 10.7270/Q2RX9D04
Bristol-Myers Squibb R&D Curated by ChEMBL					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (Homo sapiens (Human))	BDBM50150998 (((4-Methoxy-phenoxycarbonyl)-{4-[2-(5-methyl-2-phe...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	250	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of human Peroxisome proliferator activated receptor alpha				J Med Chem 48: 2248-50 (2005) Article DOI: 10.1021/jm0496436 BindingDB Entry DOI: 10.7270/Q2SX6CRR
					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (Homo sapiens (Human))	BDBM50150998 (((4-Methoxy-phenoxycarbonyl)-{4-[2-(5-methyl-2-phe...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	4.11E+3	n/a	n/a	n/a	n/a
Yuhan Research Institute Curated by ChEMBL					Assay Description Agonist activity at human PPARalpha expressed in african green monkey CV-1 by cotransfected with GAL4 by by dual-glo luciferase reporter gene assay				Bioorg Med Chem Lett 18: 4993-6 (2008) Article DOI: 10.1016/j.bmcl.2008.08.020 BindingDB Entry DOI: 10.7270/Q25B029G
Yuhan Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (Homo sapiens (Human))	BDBM50150998 (((4-Methoxy-phenoxycarbonyl)-{4-[2-(5-methyl-2-phe...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	1.41E+3	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Research and Development Curated by ChEMBL					Assay Description Binding affinity to PPARalpha (unknown origin) by fluorescence polarization assay				Bioorg Med Chem Lett 19: 1451-6 (2009) Article DOI: 10.1016/j.bmcl.2009.01.030 BindingDB Entry DOI: 10.7270/Q2MC8ZW8
					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (Homo sapiens (Human))	BDBM50150998 (((4-Methoxy-phenoxycarbonyl)-{4-[2-(5-methyl-2-phe...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	595	n/a	n/a	n/a	n/a
University of Lille Curated by ChEMBL					Assay Description Transactivation of human Gal4-fused PPARalpha LBD expressed in African green monkey COS7 cells after 24 hrs by luciferase reporter gene assay				Eur J Med Chem 137: 310-326 (2017) Article DOI: 10.1016/j.ejmech.2017.06.006 BindingDB Entry DOI: 10.7270/Q2KS6V2B
University of Lille Curated by ChEMBL					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (Homo sapiens (Human))	BDBM50150998 (((4-Methoxy-phenoxycarbonyl)-{4-[2-(5-methyl-2-phe...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	1.41E+3	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Research and Development (R&D) Curated by ChEMBL					Assay Description Agonist activity at GAL4 tagged human PPARalpha ligand binding domain expressed in HEK293 cells by luciferase reporter gene assay				Bioorg Med Chem Lett 25: 1196-205 (2015) Article DOI: 10.1016/j.bmcl.2015.01.066 BindingDB Entry DOI: 10.7270/Q20866ZP
					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (Homo sapiens (Human))	BDBM50150998 (((4-Methoxy-phenoxycarbonyl)-{4-[2-(5-methyl-2-phe...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	150	n/a	n/a	n/a	n/a
Zydus Research Centre Curated by ChEMBL					Assay Description Agonist activity at human PPARalpha transactivation expressed in human HePG2 cells				Bioorg Med Chem Lett 18: 6471-5 (2008) Article DOI: 10.1016/j.bmcl.2008.10.062 BindingDB Entry DOI: 10.7270/Q2BK1D9Z
Zydus Research Centre Curated by ChEMBL					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (Homo sapiens (Human))	BDBM50150998 (((4-Methoxy-phenoxycarbonyl)-{4-[2-(5-methyl-2-phe...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	35	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Curated by ChEMBL					Assay Description Agonist activity at PPAR alpha in human HEK cells by transactivation assay				Drug Metab Dispos 35: 150-67 (2006) Article DOI: 10.1124/dmd.106.012450 BindingDB Entry DOI: 10.7270/Q2JS9R92
Bristol-Myers Squibb Curated by ChEMBL					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (Homo sapiens (Human))	BDBM50150998 (((4-Methoxy-phenoxycarbonyl)-{4-[2-(5-methyl-2-phe...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	240	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Effective concentration against human peroxisome proliferator activated receptor alpha in Gal4 transactivation assay				J Med Chem 47: 4118-27 (2004) Article DOI: 10.1021/jm030631e BindingDB Entry DOI: 10.7270/Q2DR2TZ5
GlaxoSmithKline Curated by ChEMBL					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (Homo sapiens (Human))	BDBM50150998 (((4-Methoxy-phenoxycarbonyl)-{4-[2-(5-methyl-2-phe...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	300	n/a	n/a	n/a	n/a
Daiichi Sankyo Co., Ltd Curated by ChEMBL					Assay Description Agonist activity at GAL4-fused PPARalpha assessed as transcriptional activity by cell based assay				Bioorg Med Chem Lett 22: 7075-9 (2012) Article DOI: 10.1016/j.bmcl.2012.09.092 BindingDB Entry DOI: 10.7270/Q2HM59M5
Daiichi Sankyo Co., Ltd Curated by ChEMBL					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (Homo sapiens (Human))	BDBM50150998 (((4-Methoxy-phenoxycarbonyl)-{4-[2-(5-methyl-2-phe...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	320	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Effective concentration against human Peroxisome proliferator activated receptor alpha				J Med Chem 48: 2248-50 (2005) Article DOI: 10.1021/jm0496436 BindingDB Entry DOI: 10.7270/Q2SX6CRR
					More data for this Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (Homo sapiens (Human))	BDBM50150998 (((4-Methoxy-phenoxycarbonyl)-{4-[2-(5-methyl-2-phe...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	40	n/a	n/a	n/a	n/a
Bristol-Myers Squibb R&D Curated by ChEMBL					Assay Description Agonist activity at human PPARgamma expressed in HEK293 cells assessed as luciferase activity by GAL4 transactivation assay				Bioorg Med Chem Lett 18: 3545-50 (2008) Article DOI: 10.1016/j.bmcl.2008.05.014 BindingDB Entry DOI: 10.7270/Q2RX9D04
Bristol-Myers Squibb R&D Curated by ChEMBL					More data for this Ligand-Target Pair