Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform' and Ligand = 'BDBM127425'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM127425 (US8791131, 199) Show SMILES Cn1c2cnc3ccc(nc3c2n(C2CCOCC2)c1=O)-c1cn[nH]c1 Show InChI InChI=1S/C18H18N6O2/c1-23-15-10-19-14-3-2-13(11-8-20-21-9-11)22-16(14)17(15)24(18(23)25)12-4-6-26-7-5-12/h2-3,8-10,12H,4-7H2,1H3,(H,20,21)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	11.3	-45.4	n/a	n/a	n/a	n/a	n/a	7.4	25
Pfizer Inc. US Patent					Assay Description Compounds of the present invention were evaluated for potency against PI3-Kalpha using an in vitro kinase assay. PI3-Kalpha activity is measured in v...				US Patent US8791131 (2014) BindingDB Entry DOI: 10.7270/Q23B5XV8
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