Found 2 hits Enz. Inhib. hit(s) with Target = 'Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform' and Ligand = 'BDBM50449303' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50449303
(CHEMBL3125381)Show SMILES CC1Cc2cc(F)ccc2N1C(=O)Cc1nc(sc1C(O)=O)N1CCOCC1 Show InChI InChI=1S/C19H20FN3O4S/c1-11-8-12-9-13(20)2-3-15(12)23(11)16(24)10-14-17(18(25)26)28-19(21-14)22-4-6-27-7-5-22/h2-3,9,11H,4-8,10H2,1H3,(H,25,26) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi
Curated by ChEMBL
| Assay Description Inhibition of human PI3Kbeta after 15 mins |
Bioorg Med Chem Lett 24: 1506-10 (2014)
Article DOI: 10.1016/j.bmcl.2014.02.004 BindingDB Entry DOI: 10.7270/Q25H7HR2 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50449303
(CHEMBL3125381)Show SMILES CC1Cc2cc(F)ccc2N1C(=O)Cc1nc(sc1C(O)=O)N1CCOCC1 Show InChI InChI=1S/C19H20FN3O4S/c1-11-8-12-9-13(20)2-3-15(12)23(11)16(24)10-14-17(18(25)26)28-19(21-14)22-4-6-27-7-5-22/h2-3,9,11H,4-8,10H2,1H3,(H,25,26) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 817 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi
Curated by ChEMBL
| Assay Description Inhibition of PI3Kbeta in human PTEN-deficient PC3 cells assessed as Akt phosphorylation at S473 |
Bioorg Med Chem Lett 24: 1506-10 (2014)
Article DOI: 10.1016/j.bmcl.2014.02.004 BindingDB Entry DOI: 10.7270/Q25H7HR2 |
More data for this Ligand-Target Pair | |