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Found 1 hit Enz. Inhib. hit(s) with Target = 'Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform' and Ligand = 'BDBM341283'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM341283
PNG
(N-((3R,5S)-5-(5-chloro-3-(3-(difluorophenyl)-5-flu...)
Show SMILES Nc1nc(N)c(C#N)c(n1)N1C[C@@H](C[C@H]1c1nc2cccc(Cl)c2c(=O)n1-c1cc(F)cc(c1)-c1cccc(F)c1F)NC(=O)C(F)F
Show InChI InChI=1S/C31H21ClF5N9O2/c32-19-4-2-6-21-23(19)30(48)46(16-8-13(7-14(33)9-16)17-3-1-5-20(34)24(17)35)28(42-21)22-10-15(41-29(47)25(36)37)12-45(22)27-18(11-38)26(39)43-31(40)44-27/h1-9,15,22,25H,10,12H2,(H,41,47)(H4,39,40,43,44)/t15-,22+/m1/s1
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US Patent
n/an/a 2n/an/an/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIP3 for binding to the GRP-1 plecks...

US Patent US9765060 (2017)


BindingDB Entry DOI: 10.7270/Q2DZ0BDH
More data for this
Ligand-Target Pair