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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform' and Ligand = 'BDBM50208170'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM50208170
PNG
(CHEMBL3902629)
Show SMILES C[C@H](Nc1ncnc2[nH]cc(F)c12)c1nn2cccc2c(=O)n1-c1ccccc1 |r|
Show InChI InChI=1S/C20H16FN7O/c1-12(25-18-16-14(21)10-22-17(16)23-11-24-18)19-26-27-9-5-8-15(27)20(29)28(19)13-6-3-2-4-7-13/h2-12H,1H3,(H2,22,23,24,25)/t12-/m0/s1
PDB
MMDB

NCI pathway
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UniProtKB/SwissProt

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PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 47n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Inhibition of PI3Kdelta in human THP1 cells assessed as reduction in MCSF-stimulated akt phosphorylation at Thr308 preincubated for 30 mins followed ...


ACS Med Chem Lett 8: 118-123 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00438
BindingDB Entry DOI: 10.7270/Q2ZC84WF
More data for this
Ligand-Target Pair