Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (Homo sapiens (Human)) | BDBM198031 (US9221795, 27) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem | Article PubMed | n/a | n/a | 190 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of human full length PI3K p110gamma using phosphatidylinositol 3,4,5-trisphosphate as substrate measured after 30 mins by TR-FRET assay | Citation and Details Article DOI: 10.1021/acs.jmedchem.6b01169 BindingDB Entry DOI: 10.7270/Q20G3PV2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (Homo sapiens (Human)) | BDBM198031 (US9221795, 27) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem | Article PubMed | n/a | n/a | n/a | n/a | 581 | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of PI3K p110gamma in human basophil assessed as reduction in fMLP-induced basophil activation in presence of 25% serum by flow cytometry a... | Citation and Details Article DOI: 10.1021/acs.jmedchem.6b01169 BindingDB Entry DOI: 10.7270/Q20G3PV2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (Homo sapiens (Human)) | BDBM198031 (US9221795, 27) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem | Article PubMed | n/a | n/a | n/a | n/a | 404 | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of PI3K p110gamma in human basophil assessed as reduction in fMLP-induced basophil activation by flow cytometry analysis | Citation and Details Article DOI: 10.1021/acs.jmedchem.6b01169 BindingDB Entry DOI: 10.7270/Q20G3PV2 | |||||||||||
More data for this Ligand-Target Pair |