Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform' and Ligand = 'BDBM272777'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (Homo sapiens (Human))	BDBM272777 (US10065963, Example 177) Show SMILES CC1CN(CCS1(=O)=O)c1c(cc(Cl)c2c(ncn12)C#N)C(NC(=O)c1c(N)nn2cccnc12)C(F)(F)F Show InChI InChI=1S/C22H19ClF3N9O3S/c1-11-9-33(5-6-39(11,37)38)21-12(7-13(23)16-14(8-27)30-10-34(16)21)17(22(24,25)26)31-20(36)15-18(28)32-35-4-2-3-29-19(15)35/h2-4,7,10-11,17H,5-6,9H2,1H3,(H2,28,32)(H,31,36)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	6.7	25
Incyte Corporation US Patent					Assay Description [γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinas...				US Patent US10065963 (2018) BindingDB Entry DOI: 10.7270/Q2H41TFS
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (Homo sapiens (Human))	BDBM272777 (US10065963, Example 177) Show SMILES CC1CN(CCS1(=O)=O)c1c(cc(Cl)c2c(ncn12)C#N)C(NC(=O)c1c(N)nn2cccnc12)C(F)(F)F Show InChI InChI=1S/C22H19ClF3N9O3S/c1-11-9-33(5-6-39(11,37)38)21-12(7-13(23)16-14(8-27)30-10-34(16)21)17(22(24,25)26)31-20(36)15-18(28)32-35-4-2-3-29-19(15)35/h2-4,7,10-11,17H,5-6,9H2,1H3,(H2,28,32)(H,31,36)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description To measure the Phosphorylated Ribosomal Protein S6 (RPS6) in cell lysates, THP-1 cells (Human Acute Monocytic Leukemia) are purchased from ATCC (Mana...				US Patent US10065963 (2018) BindingDB Entry DOI: 10.7270/Q2H41TFS
					More data for this Ligand-Target Pair