Found 4 hits Enz. Inhib. hit(s) with Target = 'Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform' and Ligand = 'BDBM342550' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
(Homo sapiens (Human)) | BDBM342550
(US10329299, Compound 101 | US10675286, Compound 10...)Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#Cc3cnn(C)c3)c2c(=O)n1-c1ccccc1C |r,wD:1.0,$;;;;;;;N;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;$,(-3.79,1.15,;-2.29,1.47,;-1.81,2.94,;-.3,3.26,;.73,2.11,;.17,4.72,;-.73,5.97,;-2.27,5.97,;.17,7.21,;1.64,6.74,;2.97,7.51,;4.3,6.74,;4.3,5.2,;2.97,4.43,;1.64,5.2,;-1.26,.33,;.25,.65,;1.28,-.5,;2.79,-.17,;3.82,-1.32,;3.34,-2.78,;1.84,-3.1,;1.36,-4.57,;.88,-6.03,;.41,-7.5,;-1.06,-7.97,;-1.06,-9.51,;.41,-9.99,;.88,-11.45,;1.31,-8.74,;.81,-1.96,;-.7,-2.28,;-1.18,-3.74,;-1.73,-1.14,;-3.24,-1.46,;-4.27,-.31,;-5.77,-.63,;-6.25,-2.1,;-5.22,-3.24,;-3.71,-2.92,;-2.68,-4.06,)| Show InChI InChI=1S/C31H24N8O2/c1-19-8-4-5-11-24(19)39-25(20(2)35-30(40)27-28(32)36-38-15-7-14-33-29(27)38)16-23-10-6-9-22(26(23)31(39)41)13-12-21-17-34-37(3)18-21/h4-11,14-18,20H,1-3H3,(H,35,40)/t20-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Infinity Pharmaceuticals, Inc.
US Patent
| Assay Description Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or ... |
US Patent US9775844 (2017)
BindingDB Entry DOI: 10.7270/Q2GQ70WH |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
(Homo sapiens (Human)) | BDBM342550
(US10329299, Compound 101 | US10675286, Compound 10...)Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#Cc3cnn(C)c3)c2c(=O)n1-c1ccccc1C |r,wD:1.0,$;;;;;;;N;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;$,(-3.79,1.15,;-2.29,1.47,;-1.81,2.94,;-.3,3.26,;.73,2.11,;.17,4.72,;-.73,5.97,;-2.27,5.97,;.17,7.21,;1.64,6.74,;2.97,7.51,;4.3,6.74,;4.3,5.2,;2.97,4.43,;1.64,5.2,;-1.26,.33,;.25,.65,;1.28,-.5,;2.79,-.17,;3.82,-1.32,;3.34,-2.78,;1.84,-3.1,;1.36,-4.57,;.88,-6.03,;.41,-7.5,;-1.06,-7.97,;-1.06,-9.51,;.41,-9.99,;.88,-11.45,;1.31,-8.74,;.81,-1.96,;-.7,-2.28,;-1.18,-3.74,;-1.73,-1.14,;-3.24,-1.46,;-4.27,-.31,;-5.77,-.63,;-6.25,-2.1,;-5.22,-3.24,;-3.71,-2.92,;-2.68,-4.06,)| Show InChI InChI=1S/C31H24N8O2/c1-19-8-4-5-11-24(19)39-25(20(2)35-30(40)27-28(32)36-38-15-7-14-33-29(27)38)16-23-10-6-9-22(26(23)31(39)41)13-12-21-17-34-37(3)18-21/h4-11,14-18,20H,1-3H3,(H,35,40)/t20-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Ono Pharmaceutical Co., Ltd
| Assay Description A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec... |
Bioorg Med Chem 17: 6567-82 (2009)
BindingDB Entry DOI: 10.7270/Q2KK9F5S |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
(Homo sapiens (Human)) | BDBM342550
(US10329299, Compound 101 | US10675286, Compound 10...)Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#Cc3cnn(C)c3)c2c(=O)n1-c1ccccc1C |r,wD:1.0,$;;;;;;;N;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;$,(-3.79,1.15,;-2.29,1.47,;-1.81,2.94,;-.3,3.26,;.73,2.11,;.17,4.72,;-.73,5.97,;-2.27,5.97,;.17,7.21,;1.64,6.74,;2.97,7.51,;4.3,6.74,;4.3,5.2,;2.97,4.43,;1.64,5.2,;-1.26,.33,;.25,.65,;1.28,-.5,;2.79,-.17,;3.82,-1.32,;3.34,-2.78,;1.84,-3.1,;1.36,-4.57,;.88,-6.03,;.41,-7.5,;-1.06,-7.97,;-1.06,-9.51,;.41,-9.99,;.88,-11.45,;1.31,-8.74,;.81,-1.96,;-.7,-2.28,;-1.18,-3.74,;-1.73,-1.14,;-3.24,-1.46,;-4.27,-.31,;-5.77,-.63,;-6.25,-2.1,;-5.22,-3.24,;-3.71,-2.92,;-2.68,-4.06,)| Show InChI InChI=1S/C31H24N8O2/c1-19-8-4-5-11-24(19)39-25(20(2)35-30(40)27-28(32)36-38-15-7-14-33-29(27)38)16-23-10-6-9-22(26(23)31(39)41)13-12-21-17-34-37(3)18-21/h4-11,14-18,20H,1-3H3,(H,35,40)/t20-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Infinity Pharmaceuticals, Inc.
US Patent
| Assay Description A PI3-Kinase HTRF® assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used spec... |
US Patent US10675286 (2020)
BindingDB Entry DOI: 10.7270/Q2RX9G4R |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
(Homo sapiens (Human)) | BDBM342550
(US10329299, Compound 101 | US10675286, Compound 10...)Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#Cc3cnn(C)c3)c2c(=O)n1-c1ccccc1C |r,wD:1.0,$;;;;;;;N;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;$,(-3.79,1.15,;-2.29,1.47,;-1.81,2.94,;-.3,3.26,;.73,2.11,;.17,4.72,;-.73,5.97,;-2.27,5.97,;.17,7.21,;1.64,6.74,;2.97,7.51,;4.3,6.74,;4.3,5.2,;2.97,4.43,;1.64,5.2,;-1.26,.33,;.25,.65,;1.28,-.5,;2.79,-.17,;3.82,-1.32,;3.34,-2.78,;1.84,-3.1,;1.36,-4.57,;.88,-6.03,;.41,-7.5,;-1.06,-7.97,;-1.06,-9.51,;.41,-9.99,;.88,-11.45,;1.31,-8.74,;.81,-1.96,;-.7,-2.28,;-1.18,-3.74,;-1.73,-1.14,;-3.24,-1.46,;-4.27,-.31,;-5.77,-.63,;-6.25,-2.1,;-5.22,-3.24,;-3.71,-2.92,;-2.68,-4.06,)| Show InChI InChI=1S/C31H24N8O2/c1-19-8-4-5-11-24(19)39-25(20(2)35-30(40)27-28(32)36-38-15-7-14-33-29(27)38)16-23-10-6-9-22(26(23)31(39)41)13-12-21-17-34-37(3)18-21/h4-11,14-18,20H,1-3H3,(H,35,40)/t20-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description PI3 Kinase α, β, γ or δ activity was assayed using the PI3 Kinase HTRF® assay kit (catalogue No. 33-016) purchased from Millipore... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q25T3QBR |
More data for this Ligand-Target Pair | |